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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
pharmacology, toxicology and pharmaceutics
Antioxidants from the bark of Burkea africana, an African medicinal plant
Phytotherapy Research, Volume 16, No. 2, Year 2002
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Description
The bark of the tree Burkea africana is used medicinally in large areas of sub-Saharan Africa. The constituents responsible for its putative activity are not well known. We have investigated the bark of B. africana for antioxidant and radical scavenging activity. A hydroethanol bark extract showed high activity, and most of this activity was located in semipolar fractions of the extract. From chromatographic purification and spectroscopical structure studies, we conclude that the active constituents are proanthocyanidins. Two major components appear to be fisetinidol-(4α- → 8)-catechin 3-gallate and bis-fisetinidol-(4α- → 6, 4α- → 8)-catechin 3-gallate. The latter compound is a new natural product. Smaller amounts of monomeric flavan-3-ols (catechin, epicatechin and fisetinidol) were also found. Copyright © 2002 John Wiley & Sons, Ltd.
Authors & Co-Authors
Diallo, Drissa
Unknown Affiliation
Andersen, Øyvind M.
Norway, Bergen
Universitetet I Bergen
Malterud, Karl Egil
Norway, Oslo
Universitetet I Oslo
Statistics
Citations: 39
Authors: 3
Affiliations: 2
Identifiers
Doi:
10.1002/ptr.936
ISSN:
0951418X