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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Influence of age and carriage status on salivary IgA to Neisseria meningitidis
Epidemiology and Infection, Volume 133, No. 5, Year 2005
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Description
Asymptomatic carriage of Neisseria meningitidis is common (5-35% of individuals) while the incidence of invasive meningococcal disease is fairly low (<1-5 per 100000 per annum in Europe). Naturally acquired protective immunity may account for this difference. In this study, we investigated the relationship between anti-meningococcal salivary IgA and age and carriage. We showed that salivary IgA to a range of meningococcal antigens increased successively with age with some specificity for commonly circulating serosubtypes. In a group of 258 students 37 (14%) of whom were carriers of N. meningitidis serogroup B, higher levels of specific IgA were associated with carriage. Stratified analysis revealed a positive relationship between smoking and specific anti-N. meningitidis IgA independent of current carriage, weighted odds ratio (OR) 4.1 (95% CI 1.1-18) and OR 3.8 (95% CI 0.96-16) for reference strains B:1:P1.14 and B:4:P1.5,4 respectively. These data implicate IgA as a factor in host defence from meningococcal invasion, although the precise mechanisms remain uncertain. © 2005 Cambridge University Press.
Authors & Co-Authors
Horton, Rachel E.
United Kingdom, Bristol
University of Bristol
United Kingdom, London
Public Health England
Stuart, James Mac Naughton
United Kingdom, London
Public Health England
Borrow, Ray
United Kingdom, Manchester
Manchester Royal Infirmary
Guthrie, Terry
United Kingdom, Bristol
University of Bristol
Davenport, Victoria
United Kingdom, Bristol
University of Bristol
Finn, Adam H.R.
United Kingdom, Bristol
University of Bristol
Williams, Neil A.
United Kingdom, Bristol
University of Bristol
Heyderman, Robert Simon
United Kingdom, Bristol
University of Bristol
United Kingdom, London
Public Health England
Statistics
Citations: 28
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1017/S0950268805004097
ISSN:
09502688
Study Design
Cohort Study
Case-Control Study