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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Demonstrating zinc and iron bioavailability from intrinsically labeled microencapsulated ferrous fumarate and zinc gluconate sprinkles in young children
Journal of Nutrition, Volume 136, No. 4, Year 2006
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Description
Nutrient-nutrient interactions are an important consideration for any multiple-micronutrient formulation, including Sprinkles, a home-fortification strategy to control anemia. The objectives of this randomized controlled trial were as follows: 1) to compare the absorption of zinc at 2 doses given as Sprinkles; and 2) to examine the effect of zinc and ascorbic acid (AA) on iron absorption from Sprinkles. Seventy-five children aged 12-24 mo were randomly assigned to the following groups: 1) 5 mg of labeled zinc (67Zn) with 50 mg AA (LoZn group); b) 10 mg of labeled zinc (67Zn) with 50 mg AA (HiZn group); or 3) 5 mg zinc with no AA (control). All groups contained 30 mg of labeled iron (57Fe). Intravenous infusions labeled with 70Zn (LoZn and HiZn groups) and 58Fe (control) were administered. Blood was drawn at baseline, 48 h and 14 d later. The percentage of zinc absorbed did not differ between LoZn (geometric mean = 6.4%; min-max: 1.7-14.6) and HiZn (geometric mean = 7.5%; min-max: 3.3-18.0) groups. However, total zinc absorbed was significantly different between the LoZn (geometric mean = 0.31 mg; min-max: 0.08-0.73) and HiZn (geometric mean = 0.82 mg; min-max: 0.33-1.82) groups (P = 0.0004). Geometric mean percentage iron absorption values did not differ between the LoZn (5.9%; min-max: 0.8-21) and HiZn (4.4%; min-max: 0.6-12.3) groups and between the LoZn and control groups (5.0%; min-max: 1.4-24). We conclude that zinc in the form of Sprinkles has a low bioavailability, yet provides adequate amounts of absorbed zinc in young children, and that there is no effect of zinc or AA on iron absorption from the given formulations of Sprinkles. © 2006 American Society for Nutrition.
Authors & Co-Authors
Zlotkin, Stanley Howard
Canada, Toronto
University of Toronto
Canada, Toronto
Hospital for Sick Children University of Toronto
Schauer, Claudia S.
Canada, Toronto
Hospital for Sick Children University of Toronto
Agyei, Seth Owusu
Ghana, Accra
Health Research Unit, Ghana Health Service
Wolfson, Julian
Canada, Toronto
Hospital for Sick Children University of Toronto
Tondeur, Mélody C.
Canada, Toronto
University of Toronto
Canada, Toronto
Hospital for Sick Children University of Toronto
Asante, Kwaku Poku
Ghana, Accra
Health Research Unit, Ghana Health Service
Newton, Sam Kofi Tekyi
Ghana, Accra
Health Research Unit, Ghana Health Service
Serfass, Robert E.
United States, Galveston
The University of Texas Medical Branch at Galveston
Sharieff, Waseem
Canada, Toronto
University of Toronto
Canada, Toronto
Hospital for Sick Children University of Toronto
Statistics
Citations: 37
Authors: 9
Affiliations: 4
Identifiers
Doi:
10.1093/jn/136.4.920
ISSN:
00223166
Research Areas
Food Security
Maternal And Child Health
Study Approach
Quantitative