Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Pharmacovigilance of malaria intermittent preventive treatment in infants coupled with routine immunizations in 6 African countries
Journal of Infectious Diseases, Volume 205, No. SUPPL. 1, Year 2012
Notification
URL copied to clipboard!
Description
Background. Intermittent preventive treatment in infants (IPTi) is a new malaria control strategy coupled with the delivery of routine immunizations recommended by the World Health Organization since 2009 for countries with moderate to high endemicity. To evaluate its safety profile and identify potential new adverse events (AEs) following simultaneous administration of sulfadoxine-pyrimethamine (SP-IPTi) with immunizations, we measured AE incidence and evaluated spontaneous AE reporting. Methods. A cohort event monitoring study was conducted on 24 000 infants in 2 countries after administration of SP-IPTi during routine immunizations. Additional pharmacovigilance training and supervision were conducted to stimulate AE passive reporting in 6 African countries.Results.No serious AEs were found by active follow-up, representing 95% probability that the rate does not exceed 1 per 8000. No serious AEs were found by retrospective review of hospital registers. The rate of moderate AEs probably linked to immunization and/or SP-IPTi was 1.8 per 1000 doses (95% confidence interval, 1.50-2.00). Spontaneous reporting of AEs remained <1% of cases collected by active follow-up. Conclusions. Simultaneous administration of SP-IPTi and immunizations is a safe strategy for implementation with a low risk of serious AEs to infants. Strategies toward strengthening spontaneous reporting in Africa should include not only the provider but also beneficiaries or their caregivers. © 2012 The Author. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Authors & Co-Authors
de Sousa, Alexandra
United States, New York
Unicef
Rabarijaona, Léon Paul
United States, New York
Unicef
Tenkorang, Ofori
United States, New York
Unicef
Ghana, Accra
University of Ghana
Inkoom, Ebenezer
United States, New York
Unicef
Ravelomanantena, Hantamalala V.
Madagascar, Antananarivo
Centre National de Pharmacovigilance
Njarasoa, Sabrina
Madagascar, Antananarivo
Centre National de Pharmacovigilance
Whang, Jeremiah Nee
Ghana, Accra
University of Ghana
Ndiaye, Jean Louis Abdourahim
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Ndiaye, Youssoupha
Senegal, Dakar
Ministry of Public Health and Social Welfare
Ndiaye, Mouhamed
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Sow, Doudou Diagne
Senegal, Dakar
Université Cheikh Anta Diop de Dakar
Akadiri, Guinoussa
United States, New York
Unicef
Hassan, Jacques
United States, New York
Unicef
Dicko, Alassane A.
Mali, Bamako
University of Bamako
Sagara, Issaka
Mali, Bamako
University of Bamako
Kubalalika, Prestor
Malawi, Zomba
University of Malawi
Mathanga, Don Pascal
Malawi, Zomba
University of Malawi
Bizuneh, Ketema
United States, New York
Unicef
Randriasamimanana, Jean Rene
Madagascar, Antananarivo
Centre National de Pharmacovigilance
Recht, Judith
United States, New York
Unicef
Bjelic, Ivana
United States, New York
Unicef
Dodoo, Alexander N.O.
Ghana, Accra
University of Ghana
Statistics
Citations: 22
Authors: 22
Affiliations: 7
Identifiers
Doi:
10.1093/infdis/jir799
ISSN:
00221899
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study