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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
The prevalence of congenital and perinatal cytomegalovirus infections among newborns of seropositive mothers
Journal of Infection in Developing Countries, Volume 6, No. 5, Year 2012
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Description
Introduction: This study aimed to determine the prevalence of congenital and perinatal human cytomegalovirus (HCMV) infections among newborns in two major neonatal intensive care units (NICU) in Bahrain. Methodology: One hundred newborns comprised of 84 preterm and 16 term babies admitted to the NICUs were enrolled in the study. During the first six weeks of life, urine and saliva was obtained from the babies weekly and serial breast milk samples were obtained from the mothers. Maternal serum HCMV IgG was measured. Virus isolation and detection was done by shell vial culture and nested PCR. Results: Maternal HCMV IgG-seropositivity was 100%. Eight HCMV infections were detected comprising of three congenital and five perinatal infections. Congenital HCMV infection was found in preterm (2/84; 1.9%) and term (1/16; 6.3%) babies. HCMV DNA was detected in breast milk samples obtained during the first 10 days postpartum from all mothers whose babies had congenital HCMV. Forty-nine women provided breast milk samples between four and six weeks post-partum and HCMV DNA was detected in the breast milk of 11 women. Five (45.5%) of these eleven were mothers of babies with perinatal HCMV infection. There was no significant difference in the detection of HCMV using shell vial culture versus nested PCR method. Conclusion: The findings indicate occurrence of congenital and perinatal HCMV transmission in this setting of high maternal seropositivity. The use of shell vial culture and PCR amplification for HCMV screening in the NICU for rapid detection of infection during the early postnatal period is recommended. © 2012 Bentancor et al.
Authors & Co-Authors
AlKhawaja, Shahnaz
Bahrain, Manama
Arabian Gulf University
Ismaeel, Abdulrahman Yusuf
Bahrain, Manama
Arabian Gulf University
Botta, Giuseppe A.
Italy, Udine
Medical School
Senok, Abiola C.
Saudi Arabia, Riyadh
College of Medicine Alfaisal University
Statistics
Citations: 14
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.3855/jidc.2125
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cross Sectional Study
Participants Gender
Female