Reliability of Machine Learning in Eliminating Data Redundancy of Radiomics and Reflecting Pathophysiology in COVID-19 Pneumonia: Impact of CT Reconstruction Kernels on Accuracy

Background: Radiomical data are redundant but they might serve as a tool for lung quantitative assessment reflecting disease severity and actual physiological status of COVID-19 patients. Objective: Test the effectiveness of machine learning in eliminating data redundancy of radiomics and reflecting pathophysiologic changes in patients with COVID-19 pneumonia. Methods: We analyzed 605 cases admitted to Al Ain Hospital from 24 February to 1 July, 2020. They met the following inclusion criteria: age ≥ 18 years; inpatient admission; PCR positive for SARS-CoV-2; lung CT available at PACS. We categorized cases into 4 classes: mild <5% of pulmonary parenchymal involvement, moderate - 5-24%, severe - 25-49%, and critical ≥50 %. We used CT scans to build regression models predicting the oxygenation level, respiratory and cardiovascular functioning. Results: Radiomical findings are a reliable source of information to assess the functional status of patients with COVID-19. Machine learning models can predict the oxygenation level, respiratory and