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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Rationale and design of interstroke: A global case-control study of risk factors for stroke
Neuroepidemiology, Volume 35, No. 1, Year 2010
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Description
Stroke is a major global health problem. It is the third leading cause of death and the leading cause of adult disability. INTERHEART, a global case-control study of acute myocardial infarction in 52 countries (29,972 participants), identified nine modifiable risk factors that accounted for >90% of population-attributable risk. However, traditional risk factors (e.g. hypertension, cholesterol) appear to exert contrasting risks for stroke compared with coronary heart disease, and the etiology of stroke is far more heterogeneous. In addition, our knowledge of risk factors for stroke in low-income countries is inadequate, where a very large burden of stroke occurs. Accordingly, a similar epidemiological study is required for stroke, to inform effective population-based strategies to reduce the risk of stroke. Methods: INTERSTROKE is an international, multicenter case-control study. Cases are patients with a first stroke within 72 h of hospital presentation in whom CT or MRI is performed. Proxy respondents are used for cases unable to communicate. Etiological and topographical stroke subtype is documented for all cases. Controls are hospital- and community-based, matched for gender, ethnicity and age (±5 years). A questionnaire (cases and controls) is used to acquire information on known and proposed risk factors for stroke. Cardiovascular (e.g. blood pressure) and anthropometric (e.g. waist-to-hip ratio) measurements are obtained at the time of interview. Nonfasting blood samples and random urine samples are obtained from cases and controls. Study Significance: An effective global strategy to reduce the risk of stroke mandates systematic measurement of the contribution of the major vascular risk factors within defined ethnic groups and geographical locations. © 2010 S. Karger AG, Basel.
Authors & Co-Authors
O'Donnell, Martin J.
Canada, Hamilton
Mcmaster University
Xavier, Denis
India, Bengaluru
St. John’s Medical College
Diener, Hans Christoph W.
Germany, Essen
Universitätsklinikum Essen
Sacco, Ralph L.
United States, Miami
University of Miami Leonard M. Miller School of Medicine
Liu, Lisheng Strategies For Ischemic Syndromes Registry
China, Beijing
National Center for Cardiovascular Diseases
Zhang, Hongye
China, Beijing
National Center for Cardiovascular Diseases
Pias, P.
India, Bengaluru
St. John’s Medical College
Truelsen, Thomas Clement
Denmark, Copenhagen
Copenhagen University Hospital
Chin, Siu Lim
Canada, Hamilton
Mcmaster University
Rangarajan, Sumathy
Canada, Hamilton
Mcmaster University
DeVilliers, Laetitia
South Africa, Cape Town
University of Cape Town
Damasceno, A. Antonio Moura
Mozambique, Maputo
Universidade Eduardo Mondlane
Mondo, Charles Kiiza
Uganda, Kampala
Mulago Hospital
Lanas, Fernando T.
Chile, Temuco
Universidad de la Frontera
Avezum, Álvaro Jr
Brazil, Sao Paulo
Instituto Dante Pazzanese de Cardiologia
Díaz, Rafaël J.
Argentina, Rosario
Etudios Cardiologica Latin America, Rosario
Varigos, John D.
Australia, Clayton
Monash University
Hankey, Graeme J.
Australia, Perth
Royal Perth Hospital
Teal, Phillip A.
Canada, Vancouver
The University of British Columbia
Kapral, M.
Canada, Toronto
University of Toronto
Ryglewicz, Danuta Krystyna
Poland, Warsaw
Institute of Psychiatry and Neurology, Warszawa
Członkowska, Anna
Poland, Warsaw
Institute of Psychiatry and Neurology, Warszawa
Skowroñska, Marta
Poland, Warsaw
Institute of Psychiatry and Neurology, Warszawa
López-Jaramillo, P.
Colombia, Bucaramanga
Fundación Oftalmológica de Santander
Dans, Tony
Philippines, Manila
Philippine General Hospital
Langhorne, Peter
United Kingdom, Glasgow
University of Glasgow
Yusuf, Salim N.
Canada, Hamilton
Mcmaster University
Statistics
Citations: 27
Authors: 27
Affiliations: 20
Identifiers
Doi:
10.1159/000306058
Research Areas
Disability
Health System And Policy
Noncommunicable Diseases
Study Design
Cross Sectional Study
Case-Control Study