Involvement of IL-23 in enteropathic arthritis patients with inflammatory bowel disease: Preliminary results

The role of interleukin (IL)-23 in the pathogenesis of inflammatory bowel disease (IBD) remains unclear. The aim of this work was to study the serum level of IL-23 in IBD with and without arthritis and determine its relation to the subsets and clinical features of the disease. Thirty-seven patients with IBD including 11 with arthritis were included in the study with a mean age of 30.86±4.66 years. Twenty healthy subjects served as control. Seronegative spondyloarthropathy was present in 11 (29.73%) of the IBD patients; Crohn's disease (CD) was present in 23 and 14 had ulcerative colitis (UC). Serum level of IL-23 was measured in all patients and control by ELISA. IL-23 was significantly higher in IBD patients (46.24±27.19 pg/ml) compared to control (24.1±2.31 pg/ml) (p<0.0001) being higher in CD patients (52.57±32.78 pg/ml) compared to those with UC (35.86±6.41 pg/ml) (p=0.026). Furthermore, it was significantly higher in those with peripheral and/or axial arthritis (67.73±40.85 pg/ml) compared to patients without (37.15±10.37 pg/ml) (p=0.03). There was a tendency to a higher level in males (49.15±30.97 pg/ml) compared to females (38.4±9.54 pg/ml). Serum IL-23 is increased in IBD especially those with CD associated with arthritis and sacroiliitis. The IL-23 could be added to the biomarkers of development of arthritis in IBD patients. These results also confirm the findings of previous studies on the critical role played by IL-23 in the pathogenesis of IBDmaking it an important new therapeutic target for these patients. © Clinical Rheumatology 2014.