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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Evolutionary dynamics of multiple sublineages of H5N1 influenza viruses in Nigeria from 2006 to 2008
Journal of Virology, Volume 84, No. 7, Year 2010
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Description
Highly pathogenic A/H5N1 avian influenza (HPAI H5N1) viruses have seriously affected the Nigerian poultry industry since early 2006. Previous studies have identified multiple introductions of the virus into Nigeria and several reassortment events between cocirculating lineages. To determine the spatial, evolutionary, and population dynamics of the multiple H5N1 lineages cocirculating in Nigeria, we conducted a phylogenetic analysis of whole-genome sequences from 106 HPAI H5N1 viruses isolated between 2006 and 2008 and representing all 25 Nigerian states and the Federal Capital Territory (FCT) reporting outbreaks. We identified a major new subclade in Nigeria that is phylogenetically distinguishable from all previously identified sublineages, as well as two novel reassortment events. A detailed analysis of viral phylogeography identified two major source populations for the HPAI H5N1 virus in Nigeria, one in a major commercial poultry area (southwest region) and one in northern Nigeria, where contact between wild birds and backyard poultry is frequent. These findings suggested that migratory birds from Eastern Europe or Russia may serve an important role in the introduction of HPAI H5N1 viruses into Nigeria, although virus spread through the movement of poultry and poultry products cannot be excluded. Our study provides new insight into the genesis and evolution of H5N1 influenza viruses in Nigeria and has important implications for targeting surveillance efforts to rapidly identify the spread of the virus into and within Nigeria. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC2838112/bin/supp_84_7_3239__index.html
https://efashare.b-cdn.net/share/pmc/articles/PMC2838112/bin/supp_84_7_3239__Figure_S1.zip
https://efashare.b-cdn.net/share/pmc/articles/PMC2838112/bin/supp_84_7_3239__Figure_S2.zip
https://efashare.b-cdn.net/share/pmc/articles/PMC2838112/bin/supp_84_7_3239__Figure_S3.zip
https://efashare.b-cdn.net/share/pmc/articles/PMC2838112/bin/supp_84_7_3239__Figure_S4.zip
https://efashare.b-cdn.net/share/pmc/articles/PMC2838112/bin/supp_84_7_3239__Figure_S5.zip
https://efashare.b-cdn.net/share/pmc/articles/PMC2838112/bin/supp_84_7_3239__Figure_S6.zip
https://efashare.b-cdn.net/share/pmc/articles/PMC2838112/bin/supp_84_7_3239__Table_S1.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2838112/bin/supp_84_7_3239__Table_S2.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC2838112/bin/supp_84_7_3239__jvi02385_09_supp_fig_legends.doc
Authors & Co-Authors
Fusaro, Alice
Italy, Legnaro
Istituto Zooprofilattico Sperimentale Delle Venezie
Nelson, Martha Irene
United States, Bethesda
National Institutes of Health Nih
Joannis, Tony Manuel
Nigeria, Vom
National Veterinary Research Institute, Vom
Bertolotti, Luigi
Italy, Turin
Università Degli Studi Di Torino
Monne, Isabella
Italy, Legnaro
Istituto Zooprofilattico Sperimentale Delle Venezie
Salviato, Annalisa
Italy, Legnaro
Istituto Zooprofilattico Sperimentale Delle Venezie
Olaleyé, Olufemi D.
Nigeria, Ibadan
University College Hospital, Ibadan
Shittu, Ismaila Ademola
Nigeria, Vom
National Veterinary Research Institute, Vom
Sulaiman, Lanre Kabir
Nigeria, Vom
National Veterinary Research Institute, Vom
Lombin, Lami Hannatu
Nigeria, Vom
National Veterinary Research Institute, Vom
Capua, Ilaria
Italy, Legnaro
Istituto Zooprofilattico Sperimentale Delle Venezie
Holmes, Edward C.
United States, Bethesda
National Institutes of Health Nih
United States, University Park
Pennsylvania State University
Cattoli, Giovanni
Italy, Legnaro
Istituto Zooprofilattico Sperimentale Delle Venezie
Statistics
Citations: 47
Authors: 13
Affiliations: 6
Identifiers
Doi:
10.1128/JVI.02385-09
ISSN:
0022538X
Study Design
Cross Sectional Study
Study Locations
Nigeria