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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
High Diabetes Prevalence among Tuberculosis Cases in Kerala, India
PLoS ONE, Volume 7, No. 10, Article e46502, Year 2012
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Description
Background: While diabetes mellitus (DM) is a known risk factor for tuberculosis, the prevalence among TB patients in India is unknown. Routine screening of TB patients for DM may be an opportunity for its early diagnosis and improved management and might improve TB treatment outcomes. We conducted a cross-sectional survey of TB patients registered from June-July 2011 in the state of Kerala, India, to determine the prevalence of DM. Methodology/Principal Findings: A state-wide representative sample of TB patients in Kerala was interviewed and screened for DM using glycosylated hemoglobin (HbA1c); patients self-reporting a history of DM or those with HbA1c ≥6.5% were defined as diabetic. Among 552 TB patients screened, 243(44%) had DM - 128(23%) had previously known DM and 115(21%) were newly diagnosed - with higher prevalence among males and those aged >50years. The number needed to screen(NNS) to find one newly diagnosed case of DM was just four. Of 128 TB patients with previously known DM, 107(84%) had HbA1c ≥7% indicating poor glycemic control. Conclusions/Significance: Nearly half of TB patients in Kerala have DM, and approximately half of these patients were newly-diagnosed during this survey. Routine screening of TB patients for DM using HbA1c yielded a large number of DM cases and offered earlier management opportunities which may improve TB and DM outcomes. However, the most cost-effective ways of DM screening need to be established by futher operational research. © 2012 Balakrishnan et al.
Authors & Co-Authors
Nair, Sanjeev
India, Thiruvananthapuram
Medical College, Thiruvananthapuram
Wilson, Nevin Charles
Unknown Affiliation
Satyanarayana, Srinath
Unknown Affiliation
Dewan, Puneet Kumar
Unknown Affiliation
Kumar, Ajay Madhugiri Venkatachalaiah
Unknown Affiliation
Willis, Matthew D.
United States, Atlanta
Centers for Disease Control and Prevention
Harries, Anthony David
France, Paris
International Union Against Tuberculosis and Lung Disease
United Kingdom, London
London School of Hygiene & Tropical Medicine
Nair, Sreenivas Achuthan
Unknown Affiliation
Statistics
Citations: 180
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1371/journal.pone.0046502
ISSN:
19326203
Research Areas
Infectious Diseases
Noncommunicable Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative