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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children
American Journal of Tropical Medicine and Hygiene, Volume 81, No. 6, Year 2009
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Description
Plasmodium falciparum rosetting (the spontaneous binding of infected erythrocytes to uninfected erythrocytes) is a well-recognized parasite virulence factor. However, it is currently unclear whether rosetting is associated with all clinical forms of severe malaria, or only with specific syndromes such as cerebral malaria. We investigated the relationship between rosetting and clinical malaria in 209 Malian children enrolled in a case-control study of severe malaria. Rosetting was significantly higher in parasite isolates from severe malaria cases compared with non-severe hyperparasitemia and uncomplicated malaria controls (F2.117 = 8.15, P < 0.001). Analysis of sub-categories of severe malaria (unrousable coma, severe anemia, non-comatose neurological impairment, repeated seizures or a small heterogeneous group with signs of renal failure or jaundice) showed high levels of rosetting in all sub-categories, and no statistically significant differences in rosetting between sub-categories (F4.67 = 1.28, P = 0.28). Thus rosetting may contribute to the pathogenesis of all severe malaria syndromes in African children, and interventions to disrupt rosetting could be potential adjunctive therapies for all forms of severe malaria in Africa. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Doumbo, Ogobara K.
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Thera, Mahamadou Ali
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Koné, Abdoulaye Kassoum
Mali, Bamako
University of Bamako Faculty of Medicine, Pharmacy and Odonto-stomatology
Raza, Ahmed J.
United Kingdom, Edinburgh
The University of Edinburgh
Tempest, Louisa J.
United Kingdom, Edinburgh
The University of Edinburgh
Lyke, Kirsten E.
United States, Baltimore
University of Maryland School of Medicine
Plowe, Christopher Vv
United States, Baltimore
University of Maryland School of Medicine
Rowe, Jane Alexandra
United Kingdom, Edinburgh
The University of Edinburgh
Statistics
Citations: 112
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.4269/ajtmh.2009.09-0406
ISSN:
00029637
Research Areas
Health System And Policy
Infectious Diseases
Maternal And Child Health
Study Design
Case-Control Study