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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Accelerated clearance of plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency
Cellular Physiology and Biochemistry, Volume 24, No. 5-6, Year 2009
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Description
The course of malaria does not only depend on the virulence of the parasite Plasmodium but also on properties of host erythrocytes. Here, we show that infection of erythrocytes from human sickle cell trait (HbA/S) carriers with ring stages of P. falciparum led to significantly enhanced PGE 2 formation, Ca 2+ permeability, annexin-A7 degradation, phosphatidylserine (PS) exposure at the cell surface, and clearance by macrophages. P. berghei-infected erythrocytes from annexin-A7-deficient (annexin-A7 -/- ) mice were more rapidly cleared than infected wildtype cells. Accordingly, P. berghei-infected annexin-A7 -/- mice developed less parasitemia than wildtype mice. The cyclooxygenase inhibitor aspirin decreased erythrocyte PS exposure in infected annexin-A7 -/- mice and abolished the differences of parasitemia and survival between the genotypes. Conversely, the PGE 2 -agonist sulprostone decreased parasitemia and increased survival of wild type mice. In conclusion, PS exposure on erythrocytes results in accelerated clearance of Plasmodium ring stage-infected HbA/S or annexin-A7 -/- erythrocytes and thus confers partial protection against malaria in vivo. Copyright © 2009 S. Karger AG, Basel.
Authors & Co-Authors
Lang, Philipp Alexander
Germany, Tubingen
Eberhard Karls Universität Tübingen
Duranton, Christophe
Germany, Tubingen
Eberhard Karls Universität Tübingen
France, Nice
Université Côte D'azur
Shumilina, Ekaterina V.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kempe, Daniela S.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Lang, Karl Sebastian
Germany, Tubingen
Eberhard Karls Universität Tübingen
Föller, Michael
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kun, Juergen F.J.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Kremsner, Peter G.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Wesselborg, Sebastian
Germany, Tubingen
Eberhard Karls Universität Tübingen
Laufer, Stefan A.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Noegel, Angelika Anna
Germany, Koln
Universität zu Köln
Gulbins, Erich
Germany, Duisburg
Universität Duisburg-essen
Lang, Florian C.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Huber, Stephan M.
Germany, Tubingen
Eberhard Karls Universität Tübingen
Statistics
Citations: 126
Authors: 14
Affiliations: 5
Identifiers
Doi:
10.1159/000257529
ISSN:
10158987
Research Areas
Infectious Diseases