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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
A urinary peptidomics approach for early stages of cardiovascular disease risk: The African-PREDICT study
Hypertension Research, Volume 46, No. 2, Year 2023
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Description
Cardiovascular disease (CVD) affects individuals across the lifespan, with multiple cardiovascular (CV) risk factors increasingly present in young populations. The underlying mechanisms in early cardiovascular disease development are complex and still poorly understood. We therefore employed urinary proteomics as a novel approach to gain better insight into early CVD-related molecular pathways based on a CVD risk stratification approach. This study included 964 apparently healthy (no self-reported chronic illnesses, free from clinical symptoms of CVD) black and white men and women (aged 20–30 years old) from the African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT) study. Cardiovascular risk factors used for stratification included obesity, physical inactivity, tobacco use, high alcohol intake, hyperglycemia, dyslipidemia and hypertension. Participants were divided into low (0 risk factors), medium (1–2 risk factors) and high (≥3 risk factors) CV risk groups. We analyzed urinary peptidomics by capillary electrophoresis time-of-flight mass spectrometry. After adjusting for ethnicity, sex and age, 65 sequenced urinary peptides were differentially expressed between the CV risk groups (all q-values ≤ 0.01). These peptides included a lower abundance of collagen type I- and III-derived peptides in the high compared to the low CV risk group. With regard to noncollagen peptides, we found a lower abundance of alpha-1-antitrypsin fragments in the high compared to the low CV risk group (all q-values ≤ 0.01). Our findings indicate lower abundances of collagen types I and III in the high compared to the low CV risk group, suggesting potential early alterations in the CV extracellular matrix. © 2022, The Author(s), under exclusive licence to The Japanese Society of Hypertension.
Authors & Co-Authors
de Beer, Dalene
South Africa, Potchefstroom
North-west University
M.c Mels, Catharina
South Africa, Potchefstroom
North-west University
Schutte, Aletta E.
South Africa, Potchefstroom
North-west University
Australia, Sydney
George Institute for Global Health
Delles, Christian
United Kingdom, Glasgow
University of Glasgow
Mary, Sheon
United Kingdom, Glasgow
University of Glasgow
Mullen, William
United Kingdom, Glasgow
University of Glasgow
Mischak, Harald
Germany, Hannover
Mosaiques Diagnostics and Therapeutics ag
Kruger, Ruan
South Africa, Potchefstroom
North-west University
Statistics
Citations: 1
Authors: 8
Affiliations: 4
Identifiers
Doi:
10.1038/s41440-022-01097-7
ISSN:
09169636
Research Areas
Noncommunicable Diseases
Substance Abuse
Study Design
Cohort Study
Participants Gender
Male
Female