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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
SRMS142-based solid lipid microparticles: Application in oral delivery of glibenclamide to diabetic rats
European Journal of Pharmaceutics and Biopharmaceutics, Volume 76, No. 1, Year 2010
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Description
P90Gylation refers to the modification of lipid molecules by one or more phospholipid chains. Phospholipon® 90G (P90G) contains about 94.0% of phosphatidylcholine stabilized with 0.1% ascorbyl palmitate and is a safe (GRAS) FDA-approved parenteral excipient with wide applications in drug delivery. P90Gylated-Softisan® 142 conjugate, otherwise referred to as (SRMS142), has numerous advantages: wetting, solubilization, drug stabilization, emulsification, and modified release. Here, we report an evaluation of solid lipid microparticles (SLMs) formulated from SRMS142 systems as an alternative carrier system for oral glibenclamide administration in diabetic rats. The result of our findings showed that SRMS142 generated an imperfect matrix with numerous spaces that accommodated glibenclamide in a concentration-dependent manner up to 60.58%. The blood glucose-lowering effect of the SLMs was higher than that of a commercial sample. © 2010 Elsevier B.V.
Authors & Co-Authors
Nnamani, Petra Obioma
Nigeria, Naukka
University of Nigeria
Italy, Trieste
Area Science Park
Attama Anthony, A. Amaechi
Nigeria, Naukka
University of Nigeria
Ibezim, Emmanuel Chinedum
Nigeria, Naukka
University of Nigeria
Adikwu, Michael Umale
Nigeria, Naukka
University of Nigeria
Nigeria, Abuja
Science and Technology Education Post-basic Step-b
Statistics
Citations: 45
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/j.ejpb.2010.06.002
ISSN:
09396411
Research Areas
Health System And Policy