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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Long-term outcome of arterial lesions in Behçet disease: A series of 101 patients
Medicine, Volume 91, No. 1, Year 2012
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Description
The vasculitis of Behçet disease (BD) is distinctive because of involvement of both arteries and veins of all sizes. The concept of vasculo-Behçet disease has been adopted for cases in which vascular manifestations are present and often dominate the clinical features. While venous manifestations are frequent and have been reported in many publications, data regarding arterial lesions in patients with BD are rare and often isolated. In this study, we report the main characteristics, treatment, and long-term outcome of 101 patients with arterial lesions among a cohort of 820 (12.3%) BD patients. Factors that affect prognosis were assessed by multivariate analysis. There were 93 (91.2%) male patients; the median (Q1-Q3) age at diagnosis of BD was 33 (27-41) years. Arterial lesions included aneurysms (47.3%), occlusions (36.5%), stenosis (13.5%), and aortitis (2.7%). Lesions mainly involved the aorta (n = 25) and femoral (n = 23) and pulmonary (n = 21) arteries. Patients with arterial lesions were more frequently male (91.2% vs. 62.4%, respectively; p = 0.017) and had higher rates of venous involvement (80.4% vs. 29.8%, respectively; p < 0.001) compared to patients without arterial manifestations. Thirty-nine (38.6%) patients achieved complete remission. In multivariate analysis, the presence of venous involvement (odds ratio [OR], 0.29; 95% confidence interval [CI], 0.08-1.11) and arterial occlusive lesions (OR, 0.13; 95% CI, 0.01-1.25) were negatively associated with complete remission. The use of immunosuppressants (OR, 3.38; 95% CI, 0.87-13.23) was associated with the occurrence of complete remission. The 20-year survival rate was significantly lower in BD patients with arterial involvement than in those without arterial lesions (73% vs. 89%, respectively; p < 0.0001). In conclusion, the long-term outcome of arterial lesions in BD is poor, especially in the case of occlusive lesions and associated venous involvement. The use of immunosuppressants improved the prognosis. Copyright © 2012 by Lippincott Williams & Wilkins.
Authors & Co-Authors
Saadoun, David
France, Paris
Sorbonne Université
France, Paris
Laboratory i3
Asli, Bouchra
France, Paris
Sorbonne Université
Wechsler, Bertrand
France, Paris
Sorbonne Université
Houman, Mohammed Habib
France, Paris
Hôpital Saint-louis
Tunisia, Tunis
Hôpital la Rabta
Géri, Guillaume
France, Paris
Sorbonne Université
Desseaux, Kristel
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Piette, Jean Charles
France, Paris
Sorbonne Université
Lê Thi Huong, Du
France, Paris
Sorbonne Université
Amoura, Zahir
France, Paris
Sorbonne Université
Salem, Thouraya Ben
France, Paris
Hôpital Saint-louis
Tunisia, Tunis
Hôpital la Rabta
Cluzel, Philippe
France, Paris
Cnrs Centre National de la Recherche Scientifique
Koskas, Fabien
Unknown Affiliation
Resche-Rigon, Matthieu
France, Paris
Hôpital Universitaire Pitié Salpêtrière
Cacoub, Patrice P.
France, Paris
Sorbonne Université
Statistics
Citations: 172
Authors: 14
Affiliations: 6
Identifiers
Doi:
10.1097/MD.0b013e3182428126
ISSN:
00257974
e-ISSN:
15365964
Study Design
Cohort Study
Case-Control Study
Participants Gender
Male