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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
HLA Antigens in 16 Families with Xeroderma Pigmentosum
Tissue Antigens, Volume 9, No. 3, Year 1977
Notification
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Description
Xeroderma pigmentosum is an autosomal recessive disease. HLA‐A and ‐B typing was performed on peripheral blood lymphocytes and platelets. Sixteen Tunisian families were typed with 37 patients and 108 relatives. Genetic transmission of the disease and of the HLA system seemed to be independent in this study. Comparison of HLA gene frequencies between (unrelated) parents of patients and a control population showed no difference, proving that there is no clear association in populations between deleterious XP genes and a particular HLA gene. However, an excess of identical HLA among pairs of diseased siblings would suggest that the disease is polymorphic and a form of the XP could be linked to HLA. Copyright © 1977, Wiley Blackwell. All rights reserved
Authors & Co-Authors
Giraldo, Gaetano
United States, New York
Memorial Sloan-kettering Cancer Center
Degos, Laurent
France, Paris
Inserm
Beth, Elke
United States, New York
Memorial Sloan-kettering Cancer Center
Gharbi, R.
Tunisia, Tunis
Université de Tunis
Day, Noorbibi K.B.
United States, New York
Memorial Sloan-kettering Cancer Center
Dastot, Helene
France, Paris
Inserm
Haus, Margarete
United States, New York
Memorial Sloan-kettering Cancer Center
Reboul, Muriel
France, Paris
Inserm
Schmid, Michel
France, Paris
Inserm
Statistics
Citations: 9
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1111/j.1399-0039.1977.tb01099.x
ISSN:
00012815
e-ISSN:
13990039
Research Areas
Genetics And Genomics
Study Design
Cross Sectional Study