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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Molecular cytogenetic study of derivative chromosome 9 deletion in chronic myeloid leukemia patients
Medical Oncology, Volume 29, No. 2, Year 2012
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Description
The aims of this study are to investigate the frequency of derivative chromosome 9 (der (9)) deletion in Tunisian patients with chronic myeloid leukemia (CML) and to assess the correlation between this deletion and the cytogenetic response for patients treated with hydroxyurea (HU) or imatinib (IM). Karyotype analysis of 336 patients with CML was performed with R-banding technique. Fluorescence in situ hybridization (FISH) was carried using homebrew probes 17L7 and 248J22 for detecting, respectively, adjacent 5′ABL and 3′BCR deletions on der(9). Cytogenetic study demonstrated typical t(9;22)(q34;q11) translocation in 89.6% and variant translocation in 10.4% of patients. Interphase FISH studies showed deletion of der(9) in 59 (17.6%) of the 336 patients, 23 (39%) of them had variant rearrangements. There are 19 patients with solely 5′ABL deletion and 40 with concomitant 5′ABL and 3′BCR deletions. Cytogenetic response was evaluated during 18 months with HU or IM therapy. Our results demonstrate that (a) 3′BCR deletion is associated with 5′ABL deletion in all patients with der(9) deletions, (b) the 5′ABL and 3′BCR deletions arise simultaneously with t(9;22), (c) deletions on der(9) chromosome were frequently encountered in older patients and in patients presenting variant rearrangements, (d) both 5′ABL and 3′BCR deletions were associated with cytogenetic response failure in patients treated with HU, however, patients treated with IM and carrying der(9) deletions presented better cytogenetic response. © Springer Science+Business Media, LLC 2011.
Authors & Co-Authors
Bennour, Ayda
Tunisia, Sousse
Hopital Farhat Hached Sousse
Ouahchi, Ines
Tunisia, Sousse
Hopital Farhat Hached Sousse
Youssef, Y. B.
Tunisia, Sousse
Hopital Farhat Hached Sousse
Zaïer, Monia
Tunisia, Sousse
Hopital Farhat Hached Sousse
Laatiri, Mohamed Adnéne
Tunisia, Monastir
Chu Fattouma-bourguiba
Harrabi, Imed
Tunisia, Sousse
Hopital Farhat Hached Sousse
Meddeb, Balkis
Tunisia, Tunis
Hôpital Universitaire Aziza-othmana
Elloumi, Moez
Tunisia, Sfax
Chu Hedi-chaker
Khélif, Abderrahim
Tunisia, Sousse
Hopital Farhat Hached Sousse
Saâd, Ali
Tunisia, Sousse
Hopital Farhat Hached Sousse
Sennana, Halima
Tunisia, Sousse
Hopital Farhat Hached Sousse
Statistics
Citations: 11
Authors: 11
Affiliations: 4
Identifiers
Doi:
10.1007/s12032-011-9918-8
e-ISSN:
1559131X
Research Areas
Genetics And Genomics