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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Admixed Phylogenetic Distribution of Drug Resistant Mycobacterium tuberculosis in Saudi Arabia
PLoS ONE, Volume 8, No. 2, Article e55598, Year 2013
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Description
Background: The phylogeographical structure of Mycobacterium tuberculosis is generally bimodal in low tuberculosis (TB) incidence countries, where genetic lineages of the isolates generally differ with little strain clustering between autochthonous and foreign-born TB patients. However, less is known on this structure in Saudi Arabia-the most important hub of human migration as it hosts a total population of expatriates and pilgrims from all over the world which is equal to that of its citizens. Methodology: We explored the mycobacterial phylogenetic structure and strain molecular clustering in Saudi Arabia by genotyping 322 drug-resistant clinical isolates collected over a 12-month period in a national drug surveillance survey, using 24 locus-based MIRU-VNTR typing and spoligotyping. Principal Findings: In contrast to the cosmopolitan population of the country, almost all the known phylogeographic lineages of M. tuberculosis complex (with noticeable exception of Mycobacterium africanum/West-African 1 and 2) were detected, with Delhi/CAS (21.1%), EAI (11.2%), Beijing (11.2%) and main branches of the Euro-American super-lineage such as Ghana (14.9%), Haarlem (10.6%) and Cameroon (7.8%) being represented. Statistically significant associations of strain lineages were observed with poly-drug resistance and multi drug resistance especially among previously treated cases (p value of < = 0.001 for both types of resistance), with relative over-representation of Beijing strains in the latter category. However, there was no significant difference among Saudi and non-Saudi TB patients regarding distribution of phylogenetic lineages (p = 0.311). Moreover, 59.5% (22/37) of the strain molecular clusters were shared between the Saudi born and immigrant TB patients. Conclusions: Specific distribution of M. tuberculosis phylogeographic lineages is not observed between the autochthonous and foreign-born populations. These observations might reflect both socially favored ongoing TB transmission between the two population groups, and historically deep-rooted, prolonged contacts and trade relations of the peninsula with other world regions. More vigorous surveillance and strict adherence to tuberculosis control policies are urgently needed in the country. © 2013 Varghese et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3562184/bin/pone.0055598.s001.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3562184/bin/pone.0055598.s002.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3562184/bin/pone.0055598.s003.tif
Authors & Co-Authors
Varghese, Bright
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Supply, Philip
France, Lille
Genoscreen
France, Paris
Inserm
France, Lille
Center for Infection and Immunity of Lille Ciil
France, Lille
Université de Lille
Allix-Béguec, Caroline
France, Lille
Genoscreen
Shoukri, Mohamed M.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Omari, Ruba
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Herbawi, Mais
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Al-Hajoj, Sahal Abdulaziz M.
Saudi Arabia, Riyadh
King Faisal Specialist Hospital and Research Centre
Statistics
Citations: 26
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1371/journal.pone.0055598
e-ISSN:
19326203
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative
Study Locations
Cameroon
Ghana