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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Pregnancy and malaria exposure are associated with changes in the B cell pool and in plasma eotaxin levels
Journal of Immunology, Volume 193, No. 6, Year 2014
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Description
Pregnancy triggers immunological changes aimed to tolerate the fetus, but its impact on B lymphocytes is poorly understood. In addition, exposure to the Plasmodium parasite is associated with altered distribution of peripheral memory B cell (MBC) subsets. To study the combined impact of high malaria exposure and pregnancy in B cell subpopulations, we analyzed PBMCs from pregnant and nonpregnant individuals from a malaria-nonendemic country (Spain) and from a high malaria-endemic country (Papua New Guinea). In the malaria-naive cohorts, pregnancy was associated with a significant expansion of all switched (IgD-) MBC and a decrease of naive B cells. Malaria-exposed women had more atypical MBC and fewer marginal zone-like MBC, and their levels correlated with both Plasmodium vivax- and Plasmodium falciparum-specific plasma IgG levels. Classical but not atypical MBC were increased in P. falciparum infections. Moreover, active atypical MBC positively correlated with proinflammatory cytokine plasma concentrations and had lower surface IgG levels than the average. Decreased plasma eotaxin (CCL11) levels were associated with pregnancy and malaria exposure and also correlated with B cell subset frequencies. Additionally, active atypical and active classical MBC expressed higher levels of eotaxin receptor CCR3 than the other B cell subsets, suggesting a chemotactic effect of eotaxin on these B cell subsets. These findings are important to understand immunity to infections like malaria that result in negative outcomes for both the mother and the newborn and may have important implications on vaccine development. © 2014 by The American Association of Immunologists, Inc.
Authors & Co-Authors
Requena, Pilar
Spain, Barcelona
Instituto de Salud Global de Barcelona
United Kingdom, Liverpool
Liverpool School of Tropical Medicine
Campo, Joseph J.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Umbers, Alexandra J.
Australia, Melbourne
University of Melbourne
Ome-Kaius, Maria
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Wangnapi, Regina Alice
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Barrios, Diana
Spain, Barcelona
Instituto de Salud Global de Barcelona
Robinson, Leanne J.
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Rosanas-Urgell, Anna
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Belgium, Antwerpen
Prins Leopold Instituut Voor Tropische Geneeskunde
Ubillos, Itziar
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mayor, A. G.
Spain, Barcelona
Instituto de Salud Global de Barcelona
López, Marta J.
Spain, Madrid
Centro de Investigación Biomédica en Red de Enfermedades Raras
de Làzzari, Elisa
Spain, Barcelona
Instituto de Salud Global de Barcelona
Arev́alo-Herrera, Myriam
Colombia, Cali
Caucaseco Scientific Research Center
Fernandez-Becerra, C.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Del Portillo, Hernando A.
Spain, Barcelona
Instituto de Salud Global de Barcelona
Spain, Barcelona
Institució Catalana de Recerca I Estudis Avançats
Chitnis, Chetan E.
India, New Delhi
International Centre for Genetic Engineering and Biotechnology, new Delhi
Siba, Peter Max
Papua new Guinea, Goroka
Papua new Guinea Institute of Medical Research
Bardají, Azucena
Spain, Barcelona
Instituto de Salud Global de Barcelona
Mueller, Ivo
Australia, Melbourne
Walter and Eliza Hall Institute of Medical Research
Rogerson, Stephen J.
Australia, Melbourne
University of Melbourne
Menéndez, Clara
Spain, Barcelona
Instituto de Salud Global de Barcelona
Dobaño, Carlota
Spain, Barcelona
Instituto de Salud Global de Barcelona
Statistics
Citations: 31
Authors: 22
Affiliations: 10
Identifiers
Doi:
10.4049/jimmunol.1401037
ISSN:
00221767
Research Areas
Infectious Diseases
Maternal And Child Health
Sexual And Reproductive Health
Study Design
Cohort Study
Study Locations
Guinea
Participants Gender
Female