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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Recent introduction and rapid dissemination of chikungunya virus and dengue virus serotype 2 associated with human and mosquito coinfections in gabon, central africa
Clinical Infectious Diseases, Volume 55, No. 6, Year 2012
Notification
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Description
Background. Chikungunya virus (CHIKV) and Dengue virus serotype 2 (DENV-2) were recently introduced in central Africa, along with Aedes albopictus. Simultaneous outbreaks of CHIKV and DENV-2 have subsequently occurred, in Cameroon in 2006 and Gabon in 2007.Methods.To study the spread of the 2 viruses, we conducted active surveillance of acute febrile syndromes throughout Gabon between 2007 and 2010. Diagnostic methods included quantitative real-time reverse-transcription polymerase chain reaction, and molecular characterization was based on partial envelope gene sequences.Results.Between 2007 and 2010, 4287 acutely febrile patients were investigated for CHIKV and DENV-2 infections, of whom 1567 were CHIKV-positive, 376 DENV-2-positive, and 37 coinfected. We diagnosed 153 CHIKV and 11 DENV-2 cases in 2008, and 5 CHIKV and 9 DENV-2 cases in 2009. In 2010, CHIKV and DENV-2 caused a second large simultaneous outbreak. Among 2826 acutely febrile patients examined during this outbreak, 1112 were CHIKV-positive, 288 DENV-2-positive, and 28 coinfected. Mosquitoes were collected near the homes of coinfected patients, and 1 Aedes albopictus specimen was found to be positive for both CHIKV and DENV-2.Conclusions.These findings show the rapid dissemination of CHIKV and DENV-2 within a nonimmune population in a tropical African country, probably facilitated by the spread of Aedes albopictus. This has resulted in major simultaneous outbreaks with numerous coinfections in both human and mosquito. © 2012 The Author.
Authors & Co-Authors
Caron, Mélanie
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Montpellier
Ird Centre de Montpellier
Paupy, Christophe
France, Montpellier
Ird Centre de Montpellier
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Grard, Gilda
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Becquart, Pierre
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Montpellier
Ird Centre de Montpellier
Mombo, Illich Manfred
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Montpellier
Ird Centre de Montpellier
Nso, Branly Bikie Bi
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Kassa-Kassa, Fabrice
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Nkoghé, Dieudonné D.
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Gabon
Ministère de la Santé Publique
Leroy, Éric Maurice
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Montpellier
Ird Centre de Montpellier
Statistics
Citations: 163
Authors: 9
Affiliations: 3
Identifiers
Doi:
10.1093/cid/cis530
ISSN:
10584838
e-ISSN:
15376591
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cross Sectional Study
Study Approach
Quantitative
Study Locations
Cameroon
Gabon