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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
HLA class II alleles as markers of tuberculosis susceptibility and resistance; [O papel do HLA classe II na susceptibilidade/resistência à tuberculose]
Revista Portuguesa de Pneumologia, Volume 17, No. 1, Year 2011
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Description
Background: Not every individual exposed to Mycobacterium tuberculosis becomes infected. One host genetic factor, involved in modulating the immune response that has been studied in many ethnic groups is the association of human leukocyte antigens (HLA) with susceptibility to tuberculosis (TB). Objective: To investigate the association between TB, HLA-DRB1 and HLA-DQB1 alleles in a Portuguese population. Methods: HLA-DRB1 and HLA-DQB1 gene polymorphisms were analyzed by PCR-SSP in 92 TB patients, and 82 healthcare professionals without TB but exposed on a daily basis to infectious patients for more than two years (healthy exposed - HE). Tuberculin skin test reaction (TST), was positive in 69 individuals (all over 15 mm) in the HE group (HE+) and negative in thirteen (HE-). Results: HLA-DRB1*14 frequency is higher in the TB patients group (7 % vs. 0; p = 0.038) than in HE+. Conclusions: No genetic marker clearly indicative of disease susceptibility or resistance was identified in this study. However, HLA-DRB1*14 was more frequent in TB patients suggesting that it may be involved in the evolution infection towards active TB in our population. © 2010 Published by Elsevier España, S.L. on behalf of Sociedade Portuguesa de Pneumologia.
Authors & Co-Authors
Duarte, R. A.B.
Portugal, Porto
Universidade do Porto
Portugal, Vila Nova de Gaia
Centro Hospitalar de Vila Nova de Gaia
Villar, Miguel
Unknown Affiliation
Barros, Henrique P.
Portugal, Porto
Universidade do Porto
Costa, Paulo Pinho
Portugal, Porto
National Health Institute Doutor Ricardo Jorge Porto
Statistics
Citations: 23
Authors: 4
Affiliations: 3
Identifiers
Doi:
10.1016/S0873-2159(11)70005-8
ISSN:
08732159
Research Areas
Genetics And Genomics
Health System And Policy
Infectious Diseases
Study Design
Cross Sectional Study