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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
agricultural and biological sciences
Cumulative impact of host and viral factors on HIV-1 viral-load control during early infection
Journal of Virology, Volume 87, No. 2, Year 2013
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Description
In HIV-1 infection, the early set-point viral load strongly predicts both viral transmission and disease progression. The factors responsible for the wide spectrum of set-point viral loads are complex and likely reflect an interplay between the transmitted virus and genetically defined factors in both the transmitting source partner and the seroconverter. Indeed, analysis of 195 transmission pairs from Lusaka, Zambia, revealed that the viral loads in transmitting source partners contributed only~2% of the variance in early set-point viral loads of seroconverters (P=0.046 by univariable analysis). In multivariable models, early setpoint viral loads in seroconverting partners were a complex function of (i) the viral load in the source partner, (ii) the gender of the seroconverter, (iii) specific HLA class I alleles in the newly infected partner, and (iv) sharing of HLA-I alleles between partners in a transmission pair. Each of these factors significantly and independently contributed to the set-point viral load inthe newly infected partner, accounting for up to 37% of the variance observed and suggesting that many factors operate in concert to define the early virological phenotype in HIV-1 infection. © 2013, American Society for Microbiology.
Authors & Co-Authors
Yue, Ling
United States, Atlanta
Emory University
Prentice, Heather A.
United States, Birmingham
The University of Alabama at Birmingham
Farmer, Paul K.
United States, Atlanta
Emory University
Song, Wei
United States, Birmingham
The University of Alabama at Birmingham
He, Dongning
United States, Birmingham
The University of Alabama at Birmingham
Lakhi, Shabir
Zambia, Lusaka
Zambia-emory Hiv Research Project
Goepfert, Paul A.
United States, Birmingham
The University of Alabama at Birmingham
Gilmour, Jill W.
United States, New York
International Aids Vaccine Initiative
Allen, Susan A.
United States, Atlanta
Emory University
Tang, Jianming
United States, Birmingham
The University of Alabama at Birmingham
Kaslow, Richard A.
United States, Birmingham
The University of Alabama at Birmingham
Hunter, Eric
United States, Atlanta
Emory University
Statistics
Citations: 55
Authors: 12
Affiliations: 4
Identifiers
Doi:
10.1128/JVI.02118-12
ISSN:
0022538X
e-ISSN:
10985514
Research Areas
Infectious Diseases
Study Locations
Zambia