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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
A nationwide study of multidrug-resistant tuberculosis in Portugal 2014-2017 using epidemiological and molecular clustering analyses
BMC Infectious Diseases, Volume 19, No. 1, Article 567, Year 2019
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Description
Background: Increasing multidrug-resistant tuberculosis (MDR-TB) incidence is a major threat against TB eradication worldwide. We aim to conduct a detailed MDR-TB study in Portugal, an European country with endemic TB, combining genetic analysis and epidemiological data, in order to assess the efficiency of public health containment of MRD-TB in the country. Methods: We used published MIRU-VNTR data, that we reanalysed using a phylogenetic analysis to better describe MDR-TB cases transmission occurring in Portugal from 2014 to 2017, further enriched with epidemiological data of these cases. Results: We show an MDR-TB transmission scenario, where MDR strains likely arose and are transmitted within local chains. 63% of strains were clustered, suggesting high primary transmission (estimated as 50% using MIRU-VNTR data and 15% considering epidemiological links). These values are higher than those observed across Europe and even for sensitive strains in Portugal using similar methodologies. MDR-TB cases are associated with individuals born in Portugal and evolutionary analysis suggests a local evolution of strains. Consistently the sublineage LAM, the most common in sensitive strains in Europe, is the more frequent in Portugal in contrast with the remaining European MDR-TB picture where immigrant-associated Beijing strains are more common. Conclusions: Despite efforts to track and contain MDR-TB strains in Portugal, their transmission patterns are still as uncontrolled as that of sensitive strains, stressing the need to reinforce surveillance and containment strategies. © 2019 The Author(s).
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC6604307/bin/12879_2019_4189_MOESM1_ESM.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC6604307/bin/12879_2019_4189_MOESM2_ESM.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC6604307/bin/12879_2019_4189_MOESM3_ESM.docx
Authors & Co-Authors
Oliveira, Olena
Portugal, Braga
Universidade do Minho
Portugal, Porto
Universidade do Porto
Gaio, Rita
Portugal, Porto
Universidade do Porto
Correia-Neves, M.
Portugal, Braga
Universidade do Minho
Duarte, R. A.B.
Portugal, Porto
Universidade do Porto
Portugal, Vila Nova de Gaia
Centro Hospitalar de Vila Nova de Gaia
Rito, Teresa S.
Portugal, Braga
Universidade do Minho
Statistics
Citations: 8
Authors: 5
Affiliations: 4
Identifiers
Doi:
10.1186/s12879-019-4189-7
ISSN:
14712334
Research Areas
Genetics And Genomics
Infectious Diseases
Study Design
Cohort Study