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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Microgeographic variations in Burkitt's lymphoma incidence correlate with differences in malnutrition, malaria and Epstein-Barr virus
British Journal of Cancer, Volume 103, No. 11, Year 2010
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Description
Background: Endemic Burkitt's lymphoma (eBL) has been associated with Epstein-Barr virus (EBV) and holoendemic Plasmodium falciparum malaria. But recent evidence suggests that other risk factors are involved. Methods: We hypothesised that selenoprotein glutathione peroxidase (GPx), a surrogate of nutritional status, is an important biomarker for eBL risk. We measured plasma GPx, anthropometric markers of malnutrition, EBV viral loads and malaria parasitaemia in children aged 1-9 years (n258) from two locations in Nyanza Province, Kenya, with higher-than-expected and lower-than-expected incidence of eBL. The study participants were malaria asymptomatic children from the community. Results : Children from eBL high-incidence areas had significantly lower GPx levels, high EBV viral load and more evidence of chronic malnutrition than children from eBL low-incidence areas (all P< 0.001). Additionally, GPx levels were significantly lower in children with the highest EBV viral load and for those with P. falciparum infections (P< 0.035 and P< 0.004, respectively). Conclusions : These results suggest that selenium deficiency may be a risk factor for eBL. © 2010 Cancer Research UK.
Authors & Co-Authors
Sumba, Peter Odada
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Nairobi
Kenyatta University
Kabiru, Ephantus Wanjohi
Kenya, Nairobi
Kenyatta University
Namuyenga, Eunice
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Maseno
Maseno University
Fiore, Nancy
United States, Syracuse
Suny Upstate Medical University
Otieno, Richard O.
Kenya, Nairobi
Kenya Medical Research Institute
Kenya, Maseno
Maseno University
Moormann, Ann M.
United States, Worcester
University of Massachusetts Chan Medical School
Orago, Alloys S.S.
Kenya, Nairobi
National Aids Control Council
Rosenbaum, P. F.
United States, Syracuse
Suny Upstate Medical University
Rochford, Rosemary A.
United States, Syracuse
Suny Upstate Medical University
Statistics
Citations: 29
Authors: 9
Affiliations: 6
Identifiers
Doi:
10.1038/sj.bjc.6605947
e-ISSN:
15321827
Research Areas
Cancer
Food Security
Infectious Diseases
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Kenya