Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Risk of tuberculosis reactivation with tofacitinib (CP-690550)
Journal of Infectious Diseases, Volume 205, No. 11, Year 2012
Notification
URL copied to clipboard!
Description
Individuals with latent tuberculosis infection (LTBI) live with a risk of reactivation, and several treatments for chronic inflammatory conditions are highly associated with such reactivation. A new Janus kinase inhibitor, tofacitinib (CP-690550), has shown promising results for treatment of inflammatory disorders, thus raising concerns of risk of active tuberculosis. Our goal was to characterize the impact of tofacitinib on LTBI using a mouse model of contained tuberculosis. Our data indicate that tofacitinib reduces host containment of Mycobacterium tuberculosis and promotes bacterial replication in the lungs, suggesting tuberculosis reactivation. Tofacitinib may carry a significant risk for LTBI reactivation in humans. © 2012 The Author.
Authors & Co-Authors
Maiga, Mamoudou
United States, Baltimore
Johns Hopkins School of Medicine
Lun, Shichun
United States, Baltimore
Johns Hopkins School of Medicine
Guo, Haidan
United States, Baltimore
Johns Hopkins School of Medicine
Winglee, Kathryn
United States, Baltimore
Johns Hopkins School of Medicine
Ammerman, Nicole C.
United States, Baltimore
Johns Hopkins School of Medicine
Bishai, William R.
United States, Baltimore
Johns Hopkins School of Medicine
United States, Chevy Chase
Howard Hughes Medical Institute
South Africa, Durban
Africa Health Research Institute
Statistics
Citations: 50
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.1093/infdis/jis269
ISSN:
00221899