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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Short communication: In utero HIV infection is associated with an increased risk of nevirapine resistance in ugandan infants who were exposed to perinatal single dose nevirapine
AIDS Research and Human Retroviruses, Volume 25, No. 7, Year 2009
Notification
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Description
Use of single dose nevirapine (sdNVP) to prevent HIV mother-to-child transmission is associated with the emergence of NVP resistance in many infants who are HIV infected despite prophylaxis. We combined results from four clinical trials to analyze predictors of NVP resistance in sdNVP-exposed Ugandan infants. Samples were tested with the ViroSeq HIV Genotyping System and a sensitive point mutation assay (LigAmp, for detection of K103N, Y181C, and G190A). NVP resistance was detected at 6-8 weeks in 36 (45.0%) of 80 infants using ViroSeq and 33 (45.8%) of 72 infants using LigAmp. NVP resistance was more frequent among infants who were infected in utero than among infants who were diagnosed with HIV infection after birth by 6-8 weeks of age. Detection of NVP resistance at 6-8 weeks was not associated with HIV subtype (A vs. D), pre-NVP maternal viral load or CD4 cell count, infant viral load at 6-8 weeks, or infant sex. NVP resistance was still detected in some infants 6-12 months after sdNVP exposure. In this study, in utero HIV infection was the only factor associated with detection of NVP resistance in infants 6-8 weeks after sdNVP exposure. © 2009 Mary Ann Liebert, Inc.
Authors & Co-Authors
Church, Jessica D.
United States, Baltimore
Johns Hopkins University
Mwatha, Anthony K.
United States, Seattle
Statistical Center for Hiv/aids Research and Prevention Scharp
Bagenda, Danstan S.
Uganda, Kampala
Makerere University
Omer, Saad B.
United States, Baltimore
Johns Hopkins University
United States, Atlanta
Emory University
Donnell, Deborah J.
United States, Seattle
Statistical Center for Hiv/aids Research and Prevention Scharp
Musoke, Philippa Martha
Uganda, Kampala
Makerere University
Nakabiito, Clemensia
Uganda, Kampala
Makerere University
Eure, Chineta R.
United States, Atlanta
Centers for Disease Control and Prevention
Bakaki, Paul M.
Uganda, Kampala
Makerere University
United States, Cleveland
Case Western Reserve University
Matovu, Flavia Kiweewa
Uganda, Kampala
Makerere University
Thigpen, Michael C.
United States, Atlanta
Centers for Disease Control and Prevention
Guay, Laura A.
United States, Baltimore
Johns Hopkins University
McConnell, Michelle S.
United States, Atlanta
Centers for Disease Control and Prevention
Fowler, Mary Glenn
United States, Baltimore
Johns Hopkins University
United States, Atlanta
Centers for Disease Control and Prevention
Jackson, J. Brooks
United States, Baltimore
Johns Hopkins University
Eshleman, Susan H.
United States, Baltimore
Johns Hopkins University
United States, Baltimore
Johns Hopkins Medical Institutions
Statistics
Citations: 17
Authors: 16
Affiliations: 7
Identifiers
Doi:
10.1089/aid.2009.0003
ISSN:
08892229
Research Areas
Cancer
Infectious Diseases
Maternal And Child Health