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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Diabetic microvascular disease: An endocrine society scientific statement
Journal of Clinical Endocrinology and Metabolism, Volume 102, No. 12, Year 2017
Notification
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Description
Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs. Our understanding of the genesis of this injury and of potential interventions to prevent, limit, or reverse injury/dysfunction is continuously evolving. This statement reviews biochemical/cellular pathways involved in facilitating and abrogating microvascular injury. The statement summarizes the types of injury/dysfunction that occur in the three classical diabetes microvascular target tissues, the eye, the kidney, and the peripheral nervous system; the statement also reviews information on the effects of diabetes and insulin resistance on the microvasculature of skin, brain, adipose tissue, and cardiac and skeletal muscle. Despite extensive and intensive research, it is disappointing that microvascular complications of diabetes continue to compromise the quantity and quality of life for patients with diabetes. Hopefully, by understanding and building on current research findings, we will discover new approaches for prevention and treatment that will be effective for future generations. Copyright © 2017 Endocrine Society.
Authors & Co-Authors
Barrett, Eugene J.
United States, Charlottesville
University of Virginia
Klein, Ronald E.
United States, Madison
University of Wisconsin School of Medicine and Public Health
Klein, Barbara Eden Kobrin
United States, Madison
University of Wisconsin School of Medicine and Public Health
Hughes, Timothy M.
United States, Winston Salem
Wake Forest University School of Medicine
Freedman, Barry I.
Unknown Affiliation
Bowden, Donald W.
Unknown Affiliation
Vinik, Aaron I.
United States, Norfolk
Eastern Virginia Medical School
Statistics
Citations: 279
Authors: 7
Affiliations: 5
Identifiers
Doi:
10.1210/jc.2017-01922
ISSN:
0021972X
Research Areas
Disability
Health System And Policy
Noncommunicable Diseases
Violence And Injury