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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Novel Polyomaviruses of Nonhuman Primates: Genetic and Serological Predictors for the Existence of Multiple Unknown Polyomaviruses within the Human Population
PLoS Pathogens, Volume 9, No. 6, Article e1003429, Year 2013
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Description
Polyomaviruses are a family of small non-enveloped DNA viruses that encode oncogenes and have been associated, to greater or lesser extent, with human disease and cancer. Currently, twelve polyomaviruses are known to circulate within the human population. To further examine the diversity of human polyomaviruses, we have utilized a combinatorial approach comprised of initial degenerate primer-based PCR identification and phylogenetic analysis of nonhuman primate (NHP) polyomavirus species, followed by polyomavirus-specific serological analysis of human sera. Using this approach we identified twenty novel NHP polyomaviruses: nine in great apes (six in chimpanzees, two in gorillas and one in orangutan), five in Old World monkeys and six in New World monkeys. Phylogenetic analysis indicated that only four of the nine chimpanzee polyomaviruses (six novel and three previously identified) had known close human counterparts. To determine whether the remaining chimpanzee polyomaviruses had potential human counterparts, the major viral capsid proteins (VP1) of four chimpanzee polyomaviruses were expressed in E. coli for use as antigens in enzyme-linked immunoassay (ELISA). Human serum/plasma samples from both Côte d'Ivoire and Germany showed frequent seropositivity for the four viruses. Antibody pre-adsorption-based ELISA excluded the possibility that reactivities resulted from binding to known human polyomaviruses. Together, these results support the existence of additional polyomaviruses circulating within the human population that are genetically and serologically related to existing chimpanzee polyomaviruses. © 2013 Scuda et al.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3688531/bin/ppat.1003429.s001.tif
https://efashare.b-cdn.net/share/pmc/articles/PMC3688531/bin/ppat.1003429.s002.tif
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https://efashare.b-cdn.net/share/pmc/articles/PMC3688531/bin/ppat.1003429.s010.doc
https://efashare.b-cdn.net/share/pmc/articles/PMC3688531/bin/ppat.1003429.s011.doc
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https://efashare.b-cdn.net/share/pmc/articles/PMC3688531/bin/ppat.1003429.s016.docx
https://efashare.b-cdn.net/share/pmc/articles/PMC3688531/bin/ppat.1003429.s017.docx
Authors & Co-Authors
Scuda, Nelly
Germany, Berlin
Robert Koch Institute
Madinda, Nadège Freda
Germany, Berlin
Robert Koch Institute
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Akoua-Koffl, Chantal Gnankon
Cote D'ivoire
Bouaké University Teaching Hospital
Adjogoua, Edgard Valery
Cote D'ivoire, Abidjan
Institut Pasteur de Cote-d'ivoire
Wevers, Diana
Germany, Berlin
Robert Koch Institute
Hofmann, Jörg
Germany, Berlin
Charité – Universitätsmedizin Berlin
Cameron, Kenneth N.
United States, Denver
Morris Animal Foundation
United States, New York
Wildlife Conservation Society
Leendertz, Siv Aina Jensen
Germany, Berlin
Robert Koch Institute
Couacy-Hymann, Emmanuel
Cote D'ivoire
Lanada/laboratoire Central de la Pathologie Animale
Robbins, Martha M.
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Boesch, Christophe
Germany, Leipzig
Max-planck-institut Für Evolutionäre Anthropologie
Jarvis, Michael A.
United Kingdom, Plymouth
University of Plymouth
Moens, Ugo L.
Norway, Tromso
Uit Norges Arktiske Universitet
Mugisha, Lawrence
Uganda, Kampala
Ecohealth Research Group
Calvignac-Spencer, Sébastien
Germany, Berlin
Robert Koch Institute
Leendertz, Fabian Hubertus
Germany, Berlin
Robert Koch Institute
Ehlers, Bernhard
Germany, Berlin
Robert Koch Institute
Statistics
Citations: 42
Authors: 17
Affiliations: 11
Identifiers
Doi:
10.1371/journal.ppat.1003429
ISSN:
15537366
e-ISSN:
15537374
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Study Locations
Ivory Coast