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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1
American Journal of Human Genetics, Volume 89, No. 5, Year 2011
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Description
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 × 10-5) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery study, nine loci demonstrated association with AAA (p < 1 × 10-5). In the replication sample, the lead SNP at one of these loci, rs1466535, located within intron 1 of low-density-lipoprotein receptor-related protein 1 (LRP1) demonstrated significant association (p = 0.0042). We confirmed the association of rs1466535 and AAA in our follow-up study (p = 0.035). In a combined analysis (6228 AAA and 49182 controls), rs1466535 had a consistent effect size and direction in all sample sets (combined p = 4.52 × 10-10, odds ratio 1.15 [1.10-1.21]). No associations were seen for either rs1466535 or the 12q13.3 locus in independent association studies of coronary artery disease, blood pressure, diabetes, or hyperlipidaemia, suggesting that this locus is specific to AAA. Gene-expression studies demonstrated a trend toward increased LRP1 expression for the rs1466535 CC genotype in arterial tissues; there was a significant (p = 0.029) 1.19-fold (1.04-1.36) increase in LRP1 expression in CC homozygotes compared to TT homozygotes in aortic adventitia. Functional studies demonstrated that rs1466535 might alter a SREBP-1 binding site and influence enhancer activity at the locus. In conclusion, this study has identified a biologically plausible genetic variant associated specifically with AAA, and we suggest that this variant has a possible functional role in LRP1 expression. © 2011 The American Society of Human Genetics.
Authors & Co-Authors
Bown, Matthew J.
Unknown Affiliation
Jones, Gregory Thomas
Unknown Affiliation
Harrison, Seamus Conor
Unknown Affiliation
Wright, Benjamin J.
Unknown Affiliation
Bumpstead, Suzannah J.
Unknown Affiliation
Baas, Annette F.
Unknown Affiliation
Grétarsdóttir, Sólveig
Unknown Affiliation
Badger, Stephen A.
Unknown Affiliation
Bradley, Declan T.
Unknown Affiliation
Burnand, Kevin Guiver
Unknown Affiliation
Child, Anne H.
Unknown Affiliation
Clough, Rachel E.
Unknown Affiliation
Cockerill, Gillian W.
Unknown Affiliation
Hafez, Hany
Unknown Affiliation
Scott, David J.A.
Unknown Affiliation
Futers, Simon T.
Unknown Affiliation
Sohrabi, Soroush
Unknown Affiliation
Smith, Alberto M.
Unknown Affiliation
Thompson, Matt Merfyn
Unknown Affiliation
van Bockxmeer, Frank M.
Unknown Affiliation
Waltham, Matthew
Unknown Affiliation
Matthíasson, Stefán E.
Unknown Affiliation
Thorleifsson, Gudmar
Iceland, Reykjavik
Decode Genetics
Thorsteinsdottir, Unnur Arna
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Blankensteijn, J. D.
Unknown Affiliation
Teijink, Joep A.W.
Unknown Affiliation
Wijmenga, Cisca
Netherlands, Groningen
Rijksuniversiteit Groningen
de Graaf, Jacqueline J.
Unknown Affiliation
Kiemeney, Lambertus A.L.M.
Unknown Affiliation
Assimes, Themistocles L.
Unknown Affiliation
McPherson, Ruth
Unknown Affiliation
Folkersen, Lasse
Unknown Affiliation
Franco-Cereceda, Anders
Unknown Affiliation
Palmen, Jutta M.
Unknown Affiliation
Smith, Andrew J.P.
Unknown Affiliation
Edkins, Sarah J.
Unknown Affiliation
Gwilliam, Rhian G.
Unknown Affiliation
Hunt, Sarah E.
Unknown Affiliation
Potter, Simon C.
Unknown Affiliation
Lindholt, J. Sanddal
Unknown Affiliation
Frikke- Schmidt, Ruth
Unknown Affiliation
Tybjaerg-Hansen, Anne
Unknown Affiliation
Hughes, Anne E.
Unknown Affiliation
Golledge, Jonathan
Unknown Affiliation
Norman, Paul Edward
Unknown Affiliation
van Rij, Andrè M.
Unknown Affiliation
Powell, Janet Tinka
Unknown Affiliation
Eriksson, P. Ake
Unknown Affiliation
Stefánsson, Kári
Iceland, Reykjavik
Decode Genetics
Iceland, Reykjavik
Haskoli Islands
Thompson, John R.
Unknown Affiliation
Humphries, Steve Eric
Unknown Affiliation
Sayers, Robert D.
Unknown Affiliation
Deloukas, Panos
Unknown Affiliation
Samani, Nilesh J.
Unknown Affiliation
Schunkert, Heribert
Unknown Affiliation
König, Inke Regina
Unknown Affiliation
Kathiresan, Sekar
Unknown Affiliation
Reilly, Muredach P.
Unknown Affiliation
Hólm, Hilma
Unknown Affiliation
Preuss, Michael H.
Unknown Affiliation
Stewart, Alexandre F.R.
Unknown Affiliation
Gieger, Christian
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Absher, Devin Michael
Unknown Affiliation
Aherrahrou, Zouhair
Unknown Affiliation
Allayee, Hooman
Unknown Affiliation
Altshuler, David M.
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Anand, Sonia S.
Unknown Affiliation
Andersen, Karl K.
Unknown Affiliation
Anderson, Jeffrey L.
Unknown Affiliation
Ardissino, Diego
Unknown Affiliation
Ball, Stephen Geoffry
Unknown Affiliation
Barnes, Timothy A.
Unknown Affiliation
Becker, Diane M.
Unknown Affiliation
Becker, Lewis C.
Unknown Affiliation
Berger, Klaus Ulrich
Unknown Affiliation
Bis, Joshua C.M.
Unknown Affiliation
Boerwinkle, Eric A.
United States, Houston
University of Texas Health Science Center at Houston
Braund, Peter S.
Unknown Affiliation
Carlquist, John F.
Unknown Affiliation
Chen, Li
Unknown Affiliation
Cichon, Sven
Unknown Affiliation
Davies, Robert William
Unknown Affiliation
Dedoussis, George V.Z.
Unknown Affiliation
Dehghan, Abbas
Unknown Affiliation
Demissie, Serkalem
Unknown Affiliation
Diemert, Patrick
Unknown Affiliation
Do, Ron
Unknown Affiliation
Eifert, Sandra
Unknown Affiliation
El-Mokhtari, Nour Eddine
Unknown Affiliation
Ellis, Stephen G.
Unknown Affiliation
Elosua, Roberto
Unknown Affiliation
Engert, James C.
Unknown Affiliation
Epstein, Stephen E.
Unknown Affiliation
Dé Fairé, Ulf H.
Unknown Affiliation
Folsom, Aaron R.
Unknown Affiliation
Girelli, Domenico
Unknown Affiliation
Gudnason, V. G.
Unknown Affiliation
Gulcher, Jeffrey Robert
Unknown Affiliation
Hazen, Stanley L.
Unknown Affiliation
Hofman, Albert
Netherlands, Rotterdam
Erasmus Mc
Horne, Benjamin D.
Unknown Affiliation
Illig, Thomas
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Iribarren, Carlos
Unknown Affiliation
Kaplan, Lee M.
Unknown Affiliation
Kastelein, Johannes Jacob Pieter
Unknown Affiliation
Khaw, Kay Tee T.
Unknown Affiliation
Knowles, Joshua W.
Unknown Affiliation
Kolovou, Genovefa D.
Unknown Affiliation
Kong, Augustine
Iceland, Reykjavik
Decode Genetics
Laaksonen, Reijo M.H.
Unknown Affiliation
Lambrechts, Diether
Unknown Affiliation
Leander, Karin
Unknown Affiliation
Lettre, Guillaume
Unknown Affiliation
Li, Man
United States, Baltimore
Johns Hopkins University
Lieb, Wolfgang
Unknown Affiliation
Loley, Christina
Unknown Affiliation
Lotery, Andrew John
Unknown Affiliation
Mannucci, Piermannuccio Mannuccio M.
Unknown Affiliation
Maouche, Seraya
Unknown Affiliation
Martinelli, Nicola
Unknown Affiliation
McKeown, Pascal Patrick
Unknown Affiliation
Meisinger, Christa
Unknown Affiliation
Meitinger, Thomas A.
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Technische Universität München
Melander, Olle
Unknown Affiliation
Mooser, Vincent E.
Unknown Affiliation
Morgan, Thomas M.
Unknown Affiliation
Mühleisen, Thomas W.
Unknown Affiliation
Muhlestein, Joseph Brent
Unknown Affiliation
Münzel, Tomas F.
Unknown Affiliation
Nelson, Christopher P.
Unknown Affiliation
Nöthen, Markus Maria
Unknown Affiliation
Olivieri, Oliviero
Unknown Affiliation
Patel, Riyaz S.
Unknown Affiliation
Patterson, Chris C.
Unknown Affiliation
Peters, Annette Michael
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Peyvandi, Flora A.
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Qu, Liming
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Erdmann, Jeanette Ali
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Rader, Daniel J.
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Rallidis, Lοukianos S.
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Rice, Catherine M.
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Rosendaal, Frits Richard
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Salomaa, Veikko V.
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Sandhu, Manj S.
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Schadt, Eric E.
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Schaefer, Arne S.
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Schillert, Arne
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Schreiber, Stefan W.
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Schrezenmeir, Juergen
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Schwartz, Stephen Marc
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Siscovick, David S.
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Sivapalaratnam, Suthesh
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Soranzo, Nicole
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Spertus, John A.
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Stirrups, Kathleen E.
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Stoll, Monika
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Tang, W. H.Wlison
Unknown Affiliation
Tennstedt, Stephanie
Unknown Affiliation
Thorgeirsson, Gudmundur
Unknown Affiliation
Tomaszewski, Maciej
Unknown Affiliation
van Rij, Andre M.
Unknown Affiliation
Voight, Benjamin F.
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Wareham, Nicholas J.
United Kingdom, Cambridge
Addenbrooke's Hospital
Wichmann, Heinz Erich
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Ludwig-maximilians-universität München
Germany, Munich
Klinikum Der Universität München
Wild, Philipp S.
Unknown Affiliation
Willenborg, Christina
Unknown Affiliation
Witteman, Jacqueline C.M.
Unknown Affiliation
Ye, Shu
Unknown Affiliation
Zeller, Tanja
Unknown Affiliation
Ziegler, Andreas E.
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Cambien, François A.
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Goodall, Alison H.
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Cupples, Laura Adrienne
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Assimes, Themistocles L.
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Mar̈z, Winfried
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Hengstenberg, Christian
Unknown Affiliation
Blankenberg, Stefan S.
Unknown Affiliation
Ouwehand, Willem Hendrik
Unknown Affiliation
Hall, Alistair Scott
Unknown Affiliation
Roberts, Robert
Unknown Affiliation
O'Donnell, Christopher J.
Unknown Affiliation
Erdmann, Jeanette
Unknown Affiliation
Newton-Cheh, Christopher H.
Unknown Affiliation
Johnson, Toby
Unknown Affiliation
Tobin, Martin D.
Unknown Affiliation
Bochud, Murielle
Unknown Affiliation
Heath, Simon C.
Unknown Affiliation
Eyheramendy, Susana
Unknown Affiliation
Scott, Laura J.
United States, Ann Arbor
University of Michigan, Ann Arbor
Farrall, Martin
Unknown Affiliation
Tanaka, Toshiko
Unknown Affiliation
Chambers, John Campbell
Unknown Affiliation
Nilsson, Peter M.
Sweden, Lund
Skånes Universitetssjukhus
van der Harst, Pim
Unknown Affiliation
Grobbee, Diederick E Egbertus
Unknown Affiliation
Onland-Moret, N. Charlotte
Unknown Affiliation
Bots, Michiel L.
Unknown Affiliation
Wain, Louise V.
Unknown Affiliation
Teumer, Alexander
Unknown Affiliation
Luan, Jian'fan N.An
Unknown Affiliation
Kuusisto, Johanna K.
Finland, Kuopio
Kuopio University Hospital
McArdle, Wendy L.
Unknown Affiliation
Brown, Morris J.
Unknown Affiliation
Newhouse, Stephen J.
Unknown Affiliation
Zeggini, Eleftheria
United Kingdom, Oxford
University of Oxford
Beckmann, Jacques S.
Unknown Affiliation
Vollenweider, Peter K.
Unknown Affiliation
Waeber, Gérard
Unknown Affiliation
Waterworth, Dawn M.
Unknown Affiliation
Yuan, Xin
Unknown Affiliation
Groop, Leif C.
Sweden, Lund
Skånes Universitetssjukhus
Finland, Helsinki
Helsingin Yliopisto
Orho-Melander, Marju
Unknown Affiliation
Guarrera, Simonetta
Unknown Affiliation
Panico, Salvatore
Unknown Affiliation
Sacerdote, Carlotta
Unknown Affiliation
Vineis, Paolo
Unknown Affiliation
Barroso, Inês E.
Unknown Affiliation
Luben, Robert N.
Unknown Affiliation
Jousilahti, Pekka J.
Unknown Affiliation
Perola, Markus
Unknown Affiliation
Boehnke, Michael L.
United States, Ann Arbor
University of Michigan, Ann Arbor
Bonnycastle, Lori L.C.
United States, Bethesda
National Institutes of Health Nih
Jackson, Anne U.
United States, Ann Arbor
University of Michigan, Ann Arbor
Mohlke, Karen
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Stringham, Heather M.
United States, Ann Arbor
University of Michigan, Ann Arbor
Willer, Cristen J.
United States, Ann Arbor
University of Michigan, Ann Arbor
Bergman, Richard N.
United States, Los Angeles
Keck School of Medicine of Usc
Morken, Mario A.
United States, Bethesda
National Institutes of Health Nih
Döring, Angela
Unknown Affiliation
Pfeufer, Arne
Unknown Affiliation
Luben, Robert N.
Unknown Affiliation
McCarthy, Mark I.
United Kingdom, Oxford
University of Oxford
United Kingdom, Oxford
Churchill Hospital
Peltonen-Palotie, Leena Johanna
Unknown Affiliation
Snieder, Harold
Unknown Affiliation
Van Gilst, Wiek H.
Unknown Affiliation
Clarke, Robert Joseph
Unknown Affiliation
Goel, Anuj
Unknown Affiliation
Hamsten, Anders
Unknown Affiliation
Peden, John F.
Unknown Affiliation
Seedorf, Udo
Unknown Affiliation
Syvänen, Ann Christine
Unknown Affiliation
Tognoni, Gianni
Unknown Affiliation
Lakatta, Edward G.
Unknown Affiliation
Sanna, Serena
Unknown Affiliation
Scheet, Paul
Unknown Affiliation
Schlessinger, David
Unknown Affiliation
Scuteri, Angelo
Unknown Affiliation
Dörr, Marcus
Unknown Affiliation
Felix, Stephan Burkhard
Unknown Affiliation
Homuth, Georg
Unknown Affiliation
Rettig, Rainer
Unknown Affiliation
Völker, Uwe
Unknown Affiliation
Galán, Pilar Redondo
Unknown Affiliation
Hercberg, Serge
Unknown Affiliation
Lathrop, Mark G.
Unknown Affiliation
Zélénika, Diana
Unknown Affiliation
Williams, Frances M.K.
Unknown Affiliation
Zhai, Guangju
Unknown Affiliation
Laakso, M. M.
Finland, Kuopio
Kuopio University Hospital
Forouhi, Nita G.
Unknown Affiliation
Völzke, Henry
Unknown Affiliation
Uiterwaal, Cuno Spm
Unknown Affiliation
van der Schouw, Y. T.
Unknown Affiliation
Numans, Mattijs Everard
Unknown Affiliation
Navis, Gerjan
Unknown Affiliation
Berglund, Göran L.
Unknown Affiliation
Bingham, Sheila Anne
Unknown Affiliation
Kooner, Jaspal Singh
Unknown Affiliation
Connell, John M.C.
Unknown Affiliation
Bandinelli, Stefania S.
Unknown Affiliation
Ferrucci, Luigi G.
Unknown Affiliation
Watkins, Hugh C.
Unknown Affiliation
Spector, Tim David
Unknown Affiliation
Tuomilehto, Jaakko O.I.
Finland, Helsinki
Terveyden ja Hyvinvoinnin Laitos
Strachan, David Peter
Unknown Affiliation
Meneton, Pierre
Unknown Affiliation
J̈arvelin, Märjo Riitta R.
Unknown Affiliation
Loos, Ruth J.F.
Unknown Affiliation
Elliott, Paul E.
Unknown Affiliation
Abecasis, Gonçalo R.
United States, Ann Arbor
University of Michigan, Ann Arbor
Caulfield, Mark J.
Unknown Affiliation
Munroe, Patricia B.
Unknown Affiliation
Steinthórsdóttir, Valgerdur
Iceland, Reykjavik
Decode Genetics
Morris, Andrew Paul
United Kingdom, Oxford
University of Oxford
Dina, Christian
France, Lille
Institut Pasteur de Lille
France, Paris
Inserm
Welch, Ryan P.
United States, Ann Arbor
University of Michigan, Ann Arbor
Aulchenko, Yurii S.
Netherlands, Rotterdam
Erasmus Mc
Ferreira, Teresa
United Kingdom, Oxford
University of Oxford
Grallert, Harald
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Germany, Munich
Ludwig-maximilians-universität München
Amin, Najaf A.
Netherlands, Rotterdam
Erasmus Mc
Raychaudhuri, Soumya
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
United States, Boston
Brigham and Women's Hospital
McCarroll, Steven A.
United States, Cambridge
Broad Institute
United States, Boston
Harvard Medical School
Langenberg, Claudia C.
United Kingdom, Cambridge
Addenbrooke's Hospital
Hofmann, Oliver M.
United States, Boston
Harvard T.h. Chan School of Public Health
Dupuis, Josèe
United States, Boston
School of Public Health
United States, Framingham
Framingham Heart Study
Qi, Lu
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Harvard Medical School
Segrè, Ayellet V.
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Navarro, Pau
United Kingdom, Edinburgh
The University of Edinburgh
Balkau, Beverley J.
France, Paris
Inserm
France, Gif-sur-yvette
Université Paris-saclay
Benediktsson, Rafn
Iceland, Reykjavik
Landspitali - the National University Hospital of Iceland
Iceland, Kopavogur
Icelandic Heart Association
Bennett, Amanda J.
United Kingdom, Oxford
University of Oxford
Bengtsson-Boström, Kristina
Unknown Affiliation
Burtt, Nöel P.
United States, Cambridge
Broad Institute
Charpentier, Guillaume
France, Corbeil-essonnes
Centre Hospitalier Sud-francilien
Chines, Peter S.
United States, Bethesda
National Institutes of Health Nih
Cornelis, Marylin C.
United States, Boston
Harvard Medical School
Doney, Alex S.F.
United Kingdom, Dundee
Ninewells Hospital
Elliott, Amanda L.
United States, Cambridge
Broad Institute
United Kingdom, Oxford
University of Oxford
Erdos, Michael R.
United States, Bethesda
National Institutes of Health Nih
Fox, Caroline S.
United States, Framingham
Framingham Heart Study
United States, Boston
Brigham and Women's Hospital
Franklin, Christopher S.
United Kingdom, Edinburgh
The University of Edinburgh
Grarup, Niels
Denmark, Gentofte
Hagedorn Research Institute
Groves, Christopher James
United Kingdom, Oxford
University of Oxford
Hadjadj, Samy
France, Paris
Inserm
Hassanali, Neelam
United Kingdom, Oxford
University of Oxford
Herder, Christian
Germany, Dusseldorf
Deutsches Diabetes-zentrum
Isomaa, Bo A.
Finland, Helsinki
Folkhälsan
Johnson, Paul R.V.
United Kingdom, Oxford
University of Oxford
Jörgensen, Torben J.
Denmark, Glostrup
Amtssygehuset I Glostrup
Denmark, Copenhagen
Københavns Universitet
Klopp, Norman
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Kraft, Peter
United States, Boston
Harvard T.h. Chan School of Public Health
Lindgren, Cecilia M.
United Kingdom, Oxford
University of Oxford
Lyssenko, Valeriya
Sweden, Lund
Skånes Universitetssjukhus
Marre, Michel
France, Paris
Ap-hp Assistance Publique - Hopitaux de Paris
France, Paris
Université Paris Cité
Midthjell, Kristian
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
Narisu, Narisu
United States, Bethesda
National Institutes of Health Nih
Owen, Katharine R.
United Kingdom, Oxford
University of Oxford
Payne, Felicity
Unknown Affiliation
Perry, John R.B.
United Kingdom, Exeter
University of Exeter
Petersen, Ann Kristin
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Proença, Christine
France, Lille
Institut Pasteur de Lille
Prokopenko, Inga I.
United Kingdom, Oxford
University of Oxford
Robertson, Neil R.
United Kingdom, Oxford
University of Oxford
Rocheleau, Ghislain
Canada, Montreal
Université Mcgill
Roden, M. W.
Germany, Dusseldorf
Deutsches Diabetes-zentrum
Germany, Dusseldorf
Heinrich-heine-universität Düsseldorf
Meitinger, Thomas
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Shields, Beverley M.
United Kingdom, Exeter
University of Exeter
Strassburger, Klaus
Germany, Dusseldorf
Deutsches Diabetes-zentrum
Sun, Qi
United States, Boston
Harvard T.h. Chan School of Public Health
Swift, Amy J.
United States, Bethesda
National Institutes of Health Nih
Thorand, Barbara
Germany, Oberschleissheim
Helmholtz Center Munich German Research Center for Environmental Health
Tuomi, Tiinamaija
Finland, Helsinki
Folkhälsan
Finland, Helsinki
Helsingin Yliopisto
van Dam, Robertus Martinus
United States, Boston
Harvard Medical School
van Vliet-Ostaptchouk, Jana V.
Netherlands, Groningen
Rijksuniversiteit Groningen
Weedon, Michael N.
United Kingdom, Exeter
University of Exeter
Cauchi, Stéphane S.
France, Lille
Institut Pasteur de Lille
Gloyn, Anna L.
United Kingdom, Oxford
University of Oxford
Gyllensten, Ulf B.
Sweden, Uppsala
Uppsala Universitet
Hansen, Torben Schjødt
Denmark, Gentofte
Hagedorn Research Institute
Denmark, Odense
Syddansk Universitet
Hitman, Graham A.
United Kingdom, London
Queen Mary University of London
Hunter, D. J.
United States, Boston
Harvard T.h. Chan School of Public Health
Hveem, Kristian
Norway, Trondheim
Norges Teknisk-naturvitenskapelige Universitet
Morris, Andrew D.
United Kingdom, Dundee
Ninewells Hospital
Palmer, Colin Neil Alexander
United Kingdom, Dundee
Ninewells Hospital
Pramstaller, Peter P.
Italy, Bolzano
Eurac Research
Rudan, Igor
United Kingdom, Edinburgh
The University of Edinburgh
Croatia, Split
University of Split
Croatia, Zagreb
Klinički Bolnički Centar Sestre Milosrdnice
Sijbrands, Eric J.G.
Netherlands, Rotterdam
Erasmus Mc
Uitterlinden, André G.
Netherlands, Rotterdam
Erasmus Mc
Walker, Mark A.
United Kingdom, Newcastle
Newcastle University
Watanabe, Richard M.
United States, Los Angeles
Keck School of Medicine of Usc
United States, Los Angeles
University of Southern California
Böehm, Bernhard Otto
Germany, Ulm
Universität Ulm
Campbell, Harry
United Kingdom, Edinburgh
The University of Edinburgh
Daly, Mark J.
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
Hattersley, Andrew T.
United Kingdom, Exeter
University of Exeter
Hu, Frank B.
United States, Boston
Harvard T.h. Chan School of Public Health
United States, Boston
Harvard Medical School
Meigs, James B.
United States, Boston
Harvard Medical School
United States, Boston
Massachusetts General Hospital
Pankow, Jim S.
United States, Minneapolis
University of Minnesota Twin Cities
Pedersen, Oluf Borbye
Denmark, Gentofte
Hagedorn Research Institute
Denmark, Copenhagen
Københavns Universitet
Denmark, Aarhus
Aarhus Universitet
Florez, Jose C.
United States, Cambridge
Broad Institute
United States, Boston
Massachusetts General Hospital
United States, Boston
Harvard Medical School
Frayling, Tim M.
United Kingdom, Exeter
University of Exeter
Sladek, Robert S.
Canada, Montreal
Université Mcgill
Wilson, James F.
United Kingdom, Edinburgh
The University of Edinburgh
Froguel, Philippe
France, Lille
Institut Pasteur de Lille
United Kingdom, London
Imperial College London
van Duijn, Cornelia M.
Netherlands, Rotterdam
Erasmus Mc
Blair, Ross D.
Unknown Affiliation
Hill, Andrew A.
Unknown Affiliation
Lewis, David R.
Unknown Affiliation
Merriman, Tony R.
Unknown Affiliation
Thomson, Ian A.
Unknown Affiliation
Vasudevan, Thodur M.
Unknown Affiliation
Statistics
Citations: 154
Authors: 380
Affiliations: 64
Identifiers
Doi:
10.1016/j.ajhg.2011.10.002
ISSN:
00029297
Research Areas
Genetics And Genomics
Noncommunicable Diseases
Study Design
Cohort Study
Case-Control Study