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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Blockade of the renin-angiotensin system in hypertensive patients with atherosclerotic renal artery stenosis
Current Hypertension Reports, Volume 15, No. 5, Year 2013
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Description
Renin angiotensin system (RAS) blockers are generally considered as contraindicated when an atheromatous renal artery stenosis (ARAS) is diagnosed. The main reason is the fear of inducing renal ischemia and, hence, accelerating renal fibrosis and the progression towards end stage renal disease, albeit RAS blocker have been shown to be highly effective in controlling blood pressure. Part of the solution came by the development of the revascularization. There is now growing evidence showing no superiority of angioplasty over medical treatment on cardiovascular events and mortality, renal function and blood pressure control. Hence, RAS blockers resurfaced based on their proven beneficial effects on blood pressure control and cardiovascular prevention in high risk atherosclerotic patients. Thus, RAS blockers belong today to the standard treatment of hypertensive patients with ARAS. However they were not systematically prescribed in trials focusing on ARAS. The ongoing CORAL trial will give us further information on the place of this class of antihypertensive drugs in patients with ARAS. © Springer Science+Business Media New York 2013.
Authors & Co-Authors
Jarraya, FaïÇal
Tunisia, Sfax
Chu Hedi-chaker
Pruijm, M. T.C.
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Wuerzner, Grégoire Crossed D.Sign©goire
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Burnier, Michel
Switzerland, Lausanne
Centre Hospitalier Universitaire Vaudois
Statistics
Citations: 4
Authors: 4
Affiliations: 2
Identifiers
Doi:
10.1007/s11906-013-0376-x
ISSN:
15226417
e-ISSN:
15343111
Research Areas
Noncommunicable Diseases