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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Effect of vitamin A supplementation with BCG vaccine at birth on vitamin A status at 6 wk and 4 mo of age
American Journal of Clinical Nutrition, Volume 86, No. 4, Year 2007
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Description
Background: The effect of vitamin A supplementation (VAS) at birth on subsequent vitamin A status has not been studied. Objective: The objective was to study the effect of 50 000 IU vitamin A administered with BCG vaccine at birth on vitamin A status in both sexes. Design: Within a randomized placebo-controlled trial of VAS, we obtained blood from 614 children at 6 wk of age and from 369 mother-infant pairs at 4 mo of age. We assessed vitamin A status on the basis of serum retinol-binding protein (RBP) and measured serum C-reactive protein to monitor for concurrent infections. Results: RBP concentrations indicated vitamin A deficiency in 32% of the children at age 6 wk and in 16% at age 4 mo. VAS was not associated with higher RBP concentrations overall or in either sex. However, the effect of VAS varied with maternal education (P for interaction = 0.004): At age 6 wk, VAS was associated with higher (9%; 95% CI: 2, 17%) RBP concentrations in children of noneducated mothers but not in children of educated mothers. Overall, RBP concentrations increased between 6wkand 4moof age. The increase correlated inversely with the number of diphtheria-tetanus-pertussis (DTP) vaccines received in the interval (P = 0.009), particularly in girls (P for interaction = 0.01) and in vitamin A recipients (P = 0.01). Conclusions: Overall, VAS at birth had no effect on vitamin A status. However VAS may temporarily improve vitamin A status in the subgroup of children of noneducated mothers. In vitamin A recipients, subsequent DTP vaccines affected vitamin A status negatively. The main trial was registered at clinicaltrials.gov as NCT00168597. © 2007 American Society for Nutrition.
Authors & Co-Authors
Fisker, Ane Bærent
Ghana, Accra
Indepth Network
Denmark, Aarhus
Aarhus Universitetshospital
Lisse, Ida Maria
Denmark, Hellerup
Gentofte Hospital
Aaby, Peter
Ghana, Accra
Indepth Network
Denmark, Copenhagen
Statens Serum Institut
Erhardt, Juergen Georg
Indonesia, Depok
Universitas Indonesia
Rodrigues, Amabélia
Ghana, Accra
Indepth Network
Bibby, Bo Martin
Denmark, Aarhus
Aarhus Universitet
Benn, Christine Stabell
Denmark, Copenhagen
Statens Serum Institut
Statistics
Citations: 36
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.1093/ajcn/86.4.1032
ISSN:
00029165
Research Areas
Food Security
Maternal And Child Health
Participants Gender
Female