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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Molecular tracing of the global hepatitis C virus epidemic predicts regional patterns of hepatocellular carcinoma mortality
Gastroenterology, Volume 130, No. 3, Year 2006
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Description
Background & Aims: Molecular evolutionary analysis based on coalescent theory can provide important insights into epidemiologic processes worldwide. This approach was combined with analyses of the hepatitis C virus (HCV) epidemiologic-historical background and HCV-related hepatocellular carcinoma (HCC) in different countries. Methods: The HCV gene sequences of 131 genotype 1b (HCV-1b) strains from Japan, 38 HCV-1a strains from the United States, 33 HCV-1b strains from Spain, 27 HCV-3a strains from the former Soviet Union (FSU), 47 HCV-4a strains from Egypt, 25 HCV-5a strains from South Africa, and 24 HCV-6a strains from Hong Kong isolated in this study and previous studies were analyzed. Results: The coalescent analysis indicated that a transition from constant size to rapid exponential growth (spread time) occurred in Japan in the 1920s (HCV-1b), but not until the 1940s for the same genotype in Spain and other European countries. The spread time of HCV-1a in the United States was estimated to be in the 1960s; HCV-3a in the FSU, HCV-5a in South Africa, and HCV-6a in Hong Kong in the 1960s, mid-1950s, and late 1970s, respectively. Three different linear progression curves were determined by analysis of the relationship between HCV seroprevalence and HCC mortality in different geographic regions; a steep ascent indicated the greatest progression to HCC in Japan, a near horizontal line indicated the least progression in the United States and the FSU, and an intermediate slope was observed in Europe. Conclusions: These findings strongly suggest that the initial spread time of HCV is associated with the progression dynamics of HCC in each area, irrespective of genotype. © 2006 by the American Gastroenterological Association Institute.
Authors & Co-Authors
Tanaka, Yasuhito
Japan, Nagoya
Nagoya City University Graduate School of Medical Sciences
Kurbanov, F.
Japan, Nagoya
Nagoya City University Graduate School of Medical Sciences
Mano, Shuhei
Japan, Nagoya
Nagoya City University
Orito, Etsurou
Japan, Nagoya
Nagoya City University Graduate School of Medical Sciences
Vargas, Víctor
Spain, Barcelona
Hospital Universitari Vall D'hebron
Estebán, Juan Ignacio
Spain, Barcelona
Hospital Universitari Vall D'hebron
Yuen, Man Fung
Hong Kong, Hong Kong
The University of Hong Kong
Lai, C. L.
Hong Kong, Hong Kong
The University of Hong Kong
Kramvis, Anna
South Africa, Tygerberg
South African Medical Research Council
Kew, Michael Charles
South Africa, Tygerberg
South African Medical Research Council
Smuts, Heidi E.M.
South Africa, Cape Town
University of Cape Town
Netesov, Sergey V.
Russian Federation, Koltsovo
State Research Center of Virology and Biotechnology Vector
Alter, Harvey J.
United States, Bethesda
Nih Clinical Center Cc
Mizokami, Masashi
Japan, Nagoya
Nagoya City University Graduate School of Medical Sciences
Statistics
Citations: 122
Authors: 14
Affiliations: 8
Identifiers
Doi:
10.1053/j.gastro.2006.01.032
ISSN:
00165085
Research Areas
Cancer
Genetics And Genomics
Infectious Diseases
Study Locations
Egypt
South Africa