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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
F127/cisplatin microemulsions: In vitro, in vivo and computational studies
Applied Sciences (Switzerland), Volume 11, No. 7, Article 3006, Year 2021
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Description
The development of effective strategies for local administration of chemotherapeutic drugs, thus minimizing the adverse side effects to patients, is one of the key challenges in biomedicine and cancer research. This work reports the formulation and characterization of PluronicF127 microemulsions to enhance the bioavailability of Cisplatin (Cis). The size of Cis microemulsion was about 12.0 nm, as assessed by dynamic light scattering analysis. In vitro cytotoxic activity of free Cis and F127/Cis microemulsions were studied on malignant (C152 and MCF7) and normal (HUVEC) cells via tetrazolium (MTT) colorimetric assay. Cell morphology was also monitored. In vitro assessments revealed thatF127/Cis microemulsions induced cytotoxicity/morphological changes to a lesser extent than free Cis. Regarding in vivo experiments, F127/Cis microemulsions were injected intraperitoneally at 7 and 14 mg/kg doses into adult male Wistar rats to assess histologic and biochemical changes. In this case, the bulk Cis group caused severe histopathological changes and significant increases in serum liver enzymes and serum kidney function markers. The group treated with the 14 mg/kg dose of F127/Cis microemulsions also showed severe fatty changes and significant increases in serum liver enzymes, blood urea nitrogen, and creatinine levels. The group treated with the low dose of nano-Cis showed a significant increase in serum liver enzymes levels accompanied by mild fatty changes of the liver. Theoretical surveys were performed to get an understanding of the interplay between F127 and Cis. Results reveal that hydrogen bonding (HB) interactions with F127have an influence on the molecular properties of Cis and may playa role in the lower toxicity of F127/Cis in comparison to free Cis. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Authors & Co-Authors
Sargazi, Saman
Iran, Zahedan
Zahedan University of Medical Sciences
Hajinezhad, Mohammad Reza
Iran, Zabol
University of Zabol
Barani, Mahmood
Iran, Kerman
Daneshgahe Shahid Bahonar-e-kerman
Mukhtar, Mahwash
Hungary, Szeged
Szegedi Tudományegyetem Szte
Rahdar, Abbas A.
Iran, Zabol
University of Zabol
Baino, Francesco
Italy, Turin
Politecnico Di Torino
Pandey, Sadanand
South Korea, Gyeongsan
Yeungnam University
Statistics
Citations: 17
Authors: 7
Affiliations: 6
Identifiers
Doi:
10.3390/app11073006
ISSN:
20763417
Research Areas
Cancer
Study Design
Cross Sectional Study
Participants Gender
Male