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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Streptococcus pyogenes Colonization in Children Aged 24-59 Months in the Gambia: Impact of Live Attenuated Influenza Vaccine and Associated Serological Responses
Journal of Infectious Diseases, Volume 228, No. 7, Year 2023
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Description
Background: Immunity to Streptococcus pyogenes in high burden settings is poorly understood. We explored S. pyogenes nasopharyngeal colonization after intranasal live attenuated influenza vaccine (LAIV) among Gambian children aged 24-59 months, and resulting serological response to 7 antigens. Methods: A post hoc analysis was performed in 320 children randomized to receive LAIV at baseline (LAIV group) or not (control). S. pyogenes colonization was determined by quantitative polymerase chain reaction (qPCR) on nasopharyngeal swabs from baseline (day 0), day 7, and day 21. Anti-streptococcal IgG was quantified, including a subset with paired serum before/after S. pyogenes acquisition. Results: The point prevalence of S. pyogenes colonization was 7%-13%. In children negative at day 0, S. pyogenes was detected at day 7 or 21 in 18% of LAIV group and 11% of control group participants (P =. 12). The odds ratio (OR) for colonization over time was significantly increased in the LAIV group (day 21 vs day 0 OR, 3.18; P =. 003) but not in the control group (OR, 0.86; P =. 79). The highest IgG increases following asymptomatic colonization were seen for M1 and SpyCEP proteins. Conclusions: Asymptomatic S. pyogenes colonization appears modestly increased by LAIV, and may be immunologically significant. LAIV could be used to study influenza-S. pyogenes interactions. Clinical Trials Registration. NCT02972957. © 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Authors & Co-Authors
Keeley, Alexander Ryota
United Kingdom, London
London School of Hygiene & Tropical Medicine
United Kingdom, Sheffield
The University of Sheffield
Gambia, Banjul
Medical Research Council Laboratories Gambia
Armitage, Edwin Peter
United Kingdom, London
London School of Hygiene & Tropical Medicine
Gambia, Banjul
Medical Research Council Laboratories Gambia
Senghore, Elina
Gambia, Banjul
Medical Research Council Laboratories Gambia
Jagne, Ya Jankey
Gambia, Banjul
Medical Research Council Laboratories Gambia
Smeesters, Pierre R.
Belgium, Brussels
Université Libre de Bruxelles
Belgium, Brussels
Hospital Universitaire Des Enfants Reine Fabiola
Rossi, Omar
Italy, Verona
Glaxosmithkline Spa
Peno, Chikondi
United Kingdom, Edinburgh
University of Edinburgh, College of Medicine and Veterinary Medicine
Bogaert, Debby (Debby)
United Kingdom, Edinburgh
University of Edinburgh, College of Medicine and Veterinary Medicine
Kampmann, Beate B.
United Kingdom, London
London School of Hygiene & Tropical Medicine
Gambia, Banjul
Medical Research Council Laboratories Gambia
Germany, Berlin
Charité – Universitätsmedizin Berlin
Marks, Michael E.
United Kingdom, London
London School of Hygiene & Tropical Medicine
United Kingdom, London
University College London Hospitals Nhs Foundation Trust
United Kingdom, London
University College London
Turner, Claire E.
United Kingdom, Sheffield
The University of Sheffield
de Silva, Thushan I.
United Kingdom, London
London School of Hygiene & Tropical Medicine
United Kingdom, Sheffield
The University of Sheffield
Gambia, Banjul
Medical Research Council Laboratories Gambia
Statistics
Authors: 12
Affiliations: 11
Identifiers
Doi:
10.1093/infdis/jiad153
ISSN:
00221899
Research Areas
Maternal And Child Health
Study Design
Randomised Control Trial
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative
Study Locations
Gambia