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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Relationship between chemokine receptor expression, chemokine levels and HIV-1 replication in the lungs of persons exposed to Mycobacterium tuberculosis
European Journal of Immunology, Volume 43, No. 2, Year 2013
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Description
Increased susceptibility to tuberculosis following HIV-1 seroconversion contributes significantly to the tuberculosis epidemic in sub-Saharan Africa. Lung-specific mechanisms underlying the interaction between HIV-1 and Mycobacterium tuberculosis infection are incompletely understood. Here we address these questions by examining the effect of HIV-1 and latent M. tuberculosis co-infection on the expression of viral-entry receptors and ligands in bronchoalveolar lavage (BAL) of HIV-1-infected and -uninfected patients with and without latent M. tuberculosis infection. Irrespective of HIV-1 status, T cells from BAL expressed higher levels of the beta-chemokine receptor (CCR)5 than peripheral blood T cells, in particular the CD8+ T cells of HIV-1-infected persons showed elevated CCR5 expression. The concentrations of the CCR5 ligands RANTES and MIP-1β were elevated in the BAL of HIV-1-infected persons compared with that in HIV-1-uninfected controls. CCR5 expression and RANTES concentration correlated strongly with HIV-1 viral load in the BAL. In contrast, these alterations were not associated with M. tuberculosis sensitisation in vivo, nor did M. tuberculosis infection of BAL cells ex vivo change RANTES expression. These data suggest ongoing HIV-1 replication predominantly drives local pulmonary CCR5+ T-cell activation in HIV/latent M. tuberculosis co-infection. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC3791514/bin/eji0043-0540-sd1.pdf
Authors & Co-Authors
Kalsdorf, Barbara
South Africa, Cape Town
University of Cape Town
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Skolimowska, Keira H.
South Africa, Cape Town
University of Cape Town
United Kingdom, London
Imperial College London
Scriba, Thomas J.
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Dawson, Rodney
South Africa, Cape Town
University of Cape Town
Dheda, Keertan U.J.
South Africa, Cape Town
University of Cape Town
Wood, Kathryn
South Africa, Cape Town
University of Cape Town
Hofmeister, Jessica
Germany, Borstel
Forschungszentrum Borstel - Zentrum Für Medizin Und Biowissenschaften
Hanekom, Willem Albert
South Africa, Cape Town
University of Cape Town
South Africa, Observatory
South African Tuberculosis Vaccine Initiative
Lange, Christoph G.
Germany, Lubeck
Universitätsklinikum Schleswig-holstein Campus Lübeck
Wilkinson, Robert J.
South Africa, Cape Town
University of Cape Town
United Kingdom, London
Imperial College London
United Kingdom, London
Mrc National Institute for Medical Research
Statistics
Citations: 20
Authors: 10
Affiliations: 6
Identifiers
Doi:
10.1002/eji.201242804
e-ISSN:
15214141
Research Areas
Infectious Diseases