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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome
Nature Communications, Volume 12, No. 1, Article 3523, Year 2021
Notification
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Description
There is currently no approved treatment for primary Sjögren’s syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies is -in part- because of the heterogeneity in the clinical manifestation and pathophysiology of the disease. Finding common molecular signatures among patient subgroups could improve our understanding of disease etiology, and facilitate the development of targeted therapeutics. Here, we report, in a cross-sectional cohort, a molecular classification scheme for Sjögren’s syndrome patients based on the multi-omic profiling of whole blood samples from a European cohort of over 300 patients, and a similar number of age and gender-matched healthy volunteers. Using transcriptomic, genomic, epigenetic, cytokine expression and flow cytometry data, combined with clinical parameters, we identify four groups of patients with distinct patterns of immune dysregulation. The biomarkers we identify can be used by machine learning classifiers to sort future patients into subgroups, allowing the re-evaluation of response to treatments in clinical trials. © 2021, The Author(s).
Authors & Co-Authors
Le Dantec, Christelle
France, Paris
Inserm
Jamin, Christophe
France, Paris
Inserm
France, Brest
Centre Hospitalier Universitaire de Brest
Devauchelle-Pensec, Valérie
France, Paris
Inserm
France, Brest
Centre Hospitalier Universitaire de Brest
Cornec, Divi Y.K.
France, Paris
Inserm
France, Brest
Centre Hospitalier Universitaire de Brest
Saraux, Alain
France, Paris
Inserm
France, Brest
Centre Hospitalier Universitaire de Brest
Jousse-Joulin, Sandrine
France, Paris
Inserm
France, Brest
Centre Hospitalier Universitaire de Brest
Barbarroja, Nuria
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Rodríguez-Pintó, Ignasi
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
de Langhe, Ellen
Belgium, Leuven
Ku Leuven
Beretta, Lorenzo
Italy, Milan
Fondazione Irccs Ca' Granda Ospedale Maggiore Policlinico
Chizzolini, Carlo
Switzerland, Geneva
Hôpitaux Universitaires de Genève
Kovács, László
Hungary, Szeged
Szegedi Tudományegyetem Szte
Witte, Torsten
Germany, Hannover
Hannover Medical School
Pers, Jacques-Olivier Olivier
France, Paris
Inserm
France, Brest
Centre Hospitalier Universitaire de Brest
Lauwerys, Bernard R.
Belgium, Louvain-la-neuve
Université Catholique de Louvain
Vasconcelos, Carlos A.C.
Unknown Affiliation
Neves, Esmeralda
Belgium, Louvain-la-neuve
Université Catholique de Louvain
Faria, Raquel M.
Unknown Affiliation
Marinho, António A.P.
Unknown Affiliation
Almeida, Isabel M.
Unknown Affiliation
González-Gay, Miguel Ángel
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Blanco-Alonso, Ricardo
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Corrales, Alfonso F.
Spain, Santander
Hospital Universitario Marqués de Valdecilla
Cervera, Ricard
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Espinosa, Gerard
Spain, Barcelona
Institut D'investigacions Biomèdiques August pi I Sunyer - Idibaps
Hunzelmann, Nicolas
Germany, Koln
Uniklinik Köln
Baerlecken, Niklas Thomas
Germany, Hannover
Hannover Medical School
Collantes, Eduardo
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Ortega-Castro, Rafaela
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Aguirre, Mª Angeles
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Escudero-Contreras, A.
Spain, Cordoba
Instituto Maimónides de Investigación Biomédica de Córdoba Imibic
Raya Álvarez, Enriqué G.
Spain, Granada
Complejo Hospitalario Universitario de Granada
de Rámon, Enrique
Spain, Malaga
Hospital Regional Universitario Carlos Haya
Meroni, Pier Luigi
Italy, Milan
Università Degli Studi Di Milano
Gerosa, Maria
Italy, Milan
Università Degli Studi Di Milano
Hiepe, Falk
Germany, Berlin
Charité – Universitätsmedizin Berlin
Borghi, Maria Orietta
Italy, Milan
Università Degli Studi Di Milano
Martin, Javier
Spain, Madrid
Consejo Superior de Investigaciones Científicas
Xuereb, Laura
France, Neuilly-sur-seine
Servier
Alarcón-Riquelme, Marta Eugenia
Unknown Affiliation
Statistics
Citations: 56
Authors: 40
Affiliations: 24
Identifiers
Doi:
10.1038/s41467-021-23472-7
ISSN:
20411723
Research Areas
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Female