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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent
Human Genetics, Volume 123, No. 3, Year 2008
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Description
The insulin-like growth factor (IGF) signaling pathway is thought to play a major role in the etiology of breast cancer. Although incidence rates of breast cancer overall are lower in African Americans than in Caucasians, African-American women have a higher incidence under age 40 years, are diagnosed with more advanced disease, and have poorer prognosis. We investigated the association of breast cancer and genetic variants in genes in the IGF signaling pathway in a population-based case-control study of African-American women. We found significant associations at a locus encompassing parts of the IGFBP2 and IGFBP5 genes on chromosome 2q35, which we then replicated in a case-control study of Nigerian women. Based on those initial findings, we genotyped a total of 34 single nucleotide polymorphisms (SNPs) across the region in both study populations. Statistically significant associations with breast cancer were observed across approximately 50 kb of DNA sequence encompassing three exons in the 3′ end of IGFBP2 and three exons in the 3′ end of IGFBP5. SNPs were associated with breast cancer risk with P values as low as P = 0.0038 and P = 0.01 in African-Americans and Nigerians, respectively. This study is the first to report associations between genetic variants in IGFBP2 and IGFBP5 and breast cancer risk. © Springer-Verlag 2008.
Authors & Co-Authors
Garner, Chad P.
United States, Irvine
University of California, Irvine
Ding, Yuanchun
United States, Irvine
University of California, Irvine
John, Esther M.
United States, Fremont
Northern California Cancer Center
Ingles, Sue Ann
United States, Los Angeles
Keck School of Medicine of Usc
Olopade, Olufunmilayo Ibironke
United States, Chicago
The University of Chicago
Huo, Dezheng
United States, Chicago
The University of Chicago
Adebamowo, Clement
Nigeria, Ibadan
University of Ibadan
Ogundiran, Temidayo Olusade
Nigeria, Ibadan
University of Ibadan
Floris, Giuseppe L.
United States, Irvine
University of California, Irvine
Statistics
Citations: 25
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1007/s00439-008-0468-x
ISSN:
03406717
Research Areas
Cancer
Genetics And Genomics
Study Design
Cross Sectional Study
Cohort Study
Case-Control Study
Participants Gender
Female