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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Extragastrointestinal stromal tumors: a report of 4 cases
Annales de Chirurgie, Volume 131, No. 4, Year 2006
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Description
Gastrointestinal stromal tumors (GIST) are mesenchymal tumors that arise from the wall of the gastrointestinal tract expressing CD117 and/or the CD34. Similar tumors were described in the soft tissue of the abdomen and are so-called extragastrointestinal stromal tumors (EGIST). We report 4 new cases of EGIST. The tumors occurred in 2 women and 2 men, who ranged in age from 42 to 71 years. Three tumors arose from the soft tissue of the abdominal cavity, and the remainder arose from the retroperitoneum. They ranged in size from 10 to 27 cm. Three cases were composed purely of short fusiform cells tumors, the last case showed an epithelioid pattern. All the tumors expressed CD117. One patient presented with local recurrence and metastasis, one was lost to the follow-up and two patients were doing well. Immunohistochemistry is useful in distinguishing EGIST from other mesenchymal tumors. Intra-abdominal aggressive fibromatosis may express actin and CD117 but catenin is also positive, leiomyosarcoma expresses the actin and/or desmin but CD117 is usually negative, retroperitoneal dedifferentiated liposarcoma is CD117 negative and PS100 positive, inflammatory myofibroblastic tumor is negative for CD117 and CD34. The solitary fibrous tumor expresses CD34 and is negative to CD117. Some tumors expressing CD117 such desmoplastic round cell tumor should not be confused with EGIST. On the occasion of these four observations, we will discuss the clinical aspects and the main differential diagnoses of this tumor. © 2006 Elsevier SAS. All rights reserved.
Authors & Co-Authors
Ferchichi, Leila
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Kourda, Nadia
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Zermani, Rachida
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Aouem, J.
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Zaouche, Abdeljellil Jelil
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Abdjellil, Z.
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Najah, N.
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Baltagi-Ben Jilani, Sarrah
Tunisia, Tunis
Université de Tunis el Manar, Hôpital Charles Nicolle
Statistics
Citations: 13
Authors: 8
Affiliations: 1
Identifiers
Doi:
10.1016/j.anchir.2005.09.010
ISSN:
00033944
e-ISSN:
17683157
Research Areas
Cancer
Health System And Policy
Study Design
Cohort Study
Participants Gender
Male
Female