Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Prevalent PFMDR1 N86Y mutant Plasmodium falciparum in Madagascar despite absence of PFCRT mutant strains
American Journal of Tropical Medicine and Hygiene, Volume 76, No. 6, Year 2007
Notification
URL copied to clipboard!
Description
We assessed the status of point mutations associated with chloroquine resistance in pfcrt codon 76 and in pfmdrl codon 86 among Plasmodium falciparum isolates from symptomatic patients in 3 sites in Madagascar. The in vitro susceptibility of P. falciparum isolates to quinoline-containing drugs was also determined. All isolates (N = 117) successfully typed were pfcrt wild-type, except one from Tsiroanomandidy (1 of 27). However, 67.5% (95% CI: 58.2-75.9%) of these isolates contained mutant pfmdr1 86Y. The pfmdr1 N86Y mutation is associated with higher mefloquine susceptibility, but it did not affect the sensitivity of parasites to chloroquine or quinine. Our findings demonstrate that pfmdr1 mutant P. falciparum are prevalent in Madagascar and confirm the low prevalence of pfcrt mutant P. falciparum after 60 years of chloroquine use. They provide additional field-based evidence for increased mefloquine susceptibility in pfmdr1 mutant P. falciparum and are suggestive of the intrahost selection of pfmdr1 mutant parasites. Copyright © 2007 by The American Society of Tropical Medicine and Hygiene.
Authors & Co-Authors
Rason, Marie Ange
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Andrianantenaina, Herilalaina B.
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Ariey, Frédéric
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Cambodia
Institut Pasteur de Cambodge
Raveloson, Andrianirina
Madagascar, Antananarivo
Ministère de la Santé et du Planning Familial
Domarle, Olivier
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Randrianarivelojosia, Milijaona
Madagascar, Antananarivo
Institut Pasteur de Madagascar
Statistics
Citations: 28
Authors: 6
Affiliations: 3
Identifiers
Doi:
10.4269/ajtmh.2007.76.1079
ISSN:
00029637
Research Areas
Cancer
Genetics And Genomics
Health System And Policy
Study Design
Cross Sectional Study
Study Locations
Madagascar