Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Rickets in the Middle East: Role of environment and genetic predisposition
Journal of Clinical Endocrinology and Metabolism, Volume 93, No. 5, Year 2008
Notification
URL copied to clipboard!
Description
Context: The Middle East has a high incidence of rickets, and it is also common in Europe-dwelling children of Middle Eastern origin. Objective: The objective of the study was to explore the mechanisms leading to rickets in children of the Middle East. Design and Setting: We conducted a prospective study in 98 rachitic and 50 controls (aged 6 months to 4 yr) from university and community outpatient hospitals in Egypt and Turkey. Main Outcome Measures: We collected epidemiological, maternal, nutritional, radiographic, and biochemical parameters; markers of bone turnover; and vitamin D receptor (VDR) gene polymorphisms. Results: Epidemiological factors had a key role in pursuit of rickets; Egyptian and Turkish patients had lower (P < 0.01) dietary calcium intake than controls and the recommended dietary intakes, and serum 25-hydroxyvitamin D levels were reduced in patients, the difference with controls being significant (P < 0.001) only in Turkey, although rickets was more severe in Egypt as determined by the x-ray score (P < 0.05). In Turkey, the F VDR allele frequency was significantly (P < 0.05) increased in patients. The BB VDR genotype was associated with lower serum 25-hydroxyvitamin D levels in both patients and controls and with severity of rickets. Conclusions: In Turkey most patients had vitamin D deficiency, whereas in Egypt they had mostly calcium insufficiency combined with vitamin D deficiency. In this environ, VDR genotypes may predispose to rickets by increased frequency of the F allele. The unique environs and genetic predisposition have to be accounted for in the design of preventive measures, rather than using European or American recommended dietary intake for calcium and vitamin D. Copyright © 2008 by The Endocrine Society.
Authors & Co-Authors
Baroncelli, Giampiero I.
Italy, Pisa
Università Di Pisa
Bereket, Abdullah
Turkey, Istanbul
Marmara Üniversitesi Tip Fakültesi
El-Kholy, Mohamed S.
Egypt, Cairo
Ain Shams University
Audi, Laura
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Cesur, Yasar
Turkey, Van
Van Yüzüncü Yıl Üniversitesi
Ozkan, Behzat
Turkey, Erzurum
Ataturk University, Faculty of Medicine
Rashad, Mona
Egypt, Cairo
Ain Shams University
Fernández-Cancio, Monica
Spain, Cerdanyola Del Valles
Universitat Autònoma de Barcelona
Weisman, Yoseph
Israel, Tel Aviv-yafo
Tel Aviv University
Saggese, Giuseppe
Italy, Pisa
Università Di Pisa
Hochberg, Ze'Ev
Israel, Haifa
Technion - Israel Institute of Technology
Statistics
Citations: 132
Authors: 11
Affiliations: 8
Identifiers
Doi:
10.1210/jc.2007-1413
ISSN:
0021972X
e-ISSN:
0021972X
Research Areas
Genetics And Genomics
Maternal And Child Health
Study Design
Cohort Study
Study Locations
Egypt