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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
Nitric oxide effect on 5-hydroxytryptamine-induced vasoconstrictions of isolated smooth muscle
Pharmacological Reports, Volume 57, No. 1, Year 2005
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Description
The aim of the present study was to investigate a nitric oxide (NO) involvement in the mediation of a 5-HT-induced vasoconstriction response in the rat portal vein in vitro. Isolated rat portal vein segments were placed in organ baths for isometric force measurement. 5-HT (3 × 10-8 M-3 × 10-4M) contracted portal vein preparations (EC50 = 7 × 10-7 M) in a concentration-dependent manner. The vasoconstriction induced by 5-HT was significantly increased in endothelium-denuded vessels. Pretreatment with Nω-nitro-L-arginine methyl ester (L-NAME 100 μM) enhanced the contractive response to 5-HT either in intact or endothelium-denuded vessels. However, ketanserin (0.1 μM) abolished 5-HT-induced vasoconstrictions (EC50 = 4.6 × 10-8 M). Furthermore, a non-selective 5-HT1B/D receptor agonist, sumatriptan (1 × 10-10 M-1 × 10-5 M), induced a reduction of spontaneous rhythmic contractions also in endothelium-intact vessels. However, 5-HT- induced vasoconstriction was unaffected by propranolol (10 μM). The data support the hypothesis of the existence of serotonergic innervations modulating the contractility of vascular smooth muscle. These findings are consistent with the hypothesis that the vasoconstrictor activity of 5-HT in smooth muscle was mediated by activation of 5-HT1B/D and 5-HT2B receptor subtypes involving the endothelium-dependent mechanism. Copyright © 2005 by Institute of Pharmacology Polish Academy of Sciences.
Authors & Co-Authors
Datté, Jacques Yao
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Yapo, Paul Angoué
Cote D'ivoire, Abidjan
Abobo-adjamé Université
Offoumou, Michel Atté
Cote D'ivoire, Abidjan
Université de Cocody-abidjan
Statistics
Citations: 3
Authors: 3
Affiliations: 2
Identifiers
ISSN:
22995684
e-ISSN:
22995684