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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Sensitivities of a Rapid Test Versus an ELISA Kit for Detecting Anti-SARS-CoV-2 IgM/IgG in Sera from an Egyptian Cohort
Current Microbiology, Volume 81, No. 1, Article 24, Year 2024
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Description
This study aimed to compare diagnostic sensitivities of a rapid test (Rt) and an ELISA kit for detecting anti-SARS-CoV-2 IgM/IgG in virus-RT-PCR-positive (VPP) and virus-RT-PCR-unchecked (VPU) subjects in an Egyptian cohort during the first wave of SARS-CoV-2 infection. The results revealed higher sensitivity of the Rt for detecting IgM/IgG in the VPP subjects. Both the Rt and ELISA showed identical sensitivities for IgM detection in the VPU subjects. The ELISA was more sensitive for detecting IgG in the VPU subjects. Generally, within both the VPP and the VPU groups, Rt was more sensitive for detecting IgM/IgG among the symptomatic (S) compared to asymptomatic (AS) subjects than ELISA. Within the VPP group, the Rt was more sensitive for detecting both IgM/IgG among the AS subjects than ELISA. In the VPU group, the Rt was more sensitive for detecting IgM among the S subjects than ELISA. The ELISA was more sensitive for detecting IgM/IgG among AS subjects than the Rt. From these results we concluded that, despite the limitation of sample size, this study indicates suitability of the used Rt for detecting anti-SARS-CoV-2 IgM/IgG among S subjects and sheds light on possibility of relying on the used ELISA for IgG detection among AS human subjects. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Authors & Co-Authors
Bahgat, Mahmoud Mohamed
Egypt, Giza
National Research Centre
Nasraa, Mohamed Hassan
Egypt, Giza
National Research Centre
Nadeem, Rola
Egypt, Giza
National Research Centre
Amer, Khaled E.
Egypt, Cairo
Egypt Center for Research and Regenerative Medicine
Hassan, Wael A.
Egypt, Cairo
Egypt Center for Research and Regenerative Medicine
Reda, Salem
Egypt, Cairo
Egypt Center for Research and Regenerative Medicine
Förstner, Konrad U.
Unknown Affiliation
Abd-Elshafy, Dina Nadeem
Egypt, Giza
National Research Centre
Statistics
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1007/s00284-023-03473-z
ISSN:
03438651
Study Design
Cohort Study