Skip to content
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Menu
Home
About Us
Resources
Profiles Metrics
Authors Directory
Institutions Directory
Top Authors
Top Institutions
Top Sponsors
AI Digest
Contact Us
Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
general
Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal HIV-1 transmission
Proceedings of the National Academy of Sciences of the United States of America, Volume 103, No. 18, Year 2006
Notification
URL copied to clipboard!
Description
Single-dose nevirapine (sdNVP) for prevention of mother-to-child transmission of HIV-1 can select nevirapine (NVP)-resistant variants, but the frequency, duration, and clinical significance of this resistance is not well defined. We used a sensitive allele-specific PCR assay to assess the emergence and persistence of NVP-resistant variants in plasma samples from 22 women with HIV-1 subtype C infection who participated in a study of sdNVP for prevention of mother-to-child transmission of HIV-1. The women were categorized into three groups on the basis of detection of NVP resistance by standard genotype analysis. Group 1 (n = 6) had NVP resistance detected at 2 and 6 mo after sdNVP, but not at 12 mo. Group 2 (n = 9) had NVP resistance detected at 2 mo, but not 6 mo. Group 3 (n = 7) had no NVP resistance detected at any time point. Allele-specific PCR analysis for the two most common NVP resistance mutations (K103N and Y181C) detected NVP-resistant variants in most (16 of 21) samples that were negative for NVP resistance by standard genotype, at levels ranging from 0.1 % to 20% 1 yr after treatment. The frequency of NVP-resistant mutations decreased over time, but persisted above predose levels for more than 1 yrin ≥23% of the women. These findings highlight the urgent need for studies assessing the impact of sdNVP on the efficacy of subsequent, antiretroviral therapy containing NVP or other nonnucleoside reverse transcriptase inhibitors. © 2006 by The National Academy of Sciences of the USA.
Authors & Co-Authors
Palmer, S.
United States, Frederick
National Cancer Institute at Frederick
Boltz, V.
United States, Frederick
National Cancer Institute at Frederick
Martinson, Neil Alexander
South Africa, Johannesburg
University of the Witwatersrand
United States, Baltimore
Johns Hopkins University
Maldarelli, Frank M.
United States, Frederick
National Cancer Institute at Frederick
Gray, Glenda E.
South Africa, Johannesburg
University of the Witwatersrand
McIntyre, James Alasdair
South Africa, Johannesburg
University of the Witwatersrand
Mellors, John W.
United States, Pittsburgh
University of Pittsburgh
Morris, Lynn
South Africa, Johannesburg
National Institute for Communicable Diseases
Coffin, John M.
United States, Frederick
National Cancer Institute at Frederick
Statistics
Citations: 154
Authors: 9
Affiliations: 5
Identifiers
Doi:
10.1073/pnas.0602033103
ISSN:
00278424
Research Areas
Genetics And Genomics
Infectious Diseases
Maternal And Child Health
Participants Gender
Female