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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Loss of memory CD4
+
T-cells in semi-wild mandrills (Mandrillus sphinx) naturally infected with speciesspecific simian immunodeficiency virus SIVmnd-1
Journal of General Virology, Volume 95, No. PART 1, Year 2014
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Description
Simian immunodeficiency virus (SIV) infection is found in a number of African primate species and is thought to be generally non-pathogenic. However, studies of wild primates are limited to two species, with SIV infection appearing to have a considerably different outcome in each. Further examination of SIV-infected primates exposed to their natural environment is therefore warranted. We performed a large cross-sectional study of a cohort of semi-wild mandrills with naturally occurring SIV infection, including 39 SIV-negative and 33 species-specific SIVmnd-1-infected animals. This study was distinguished from previous reports by considerably greater sample size, examination of exclusively naturally infected animals in semi-wild conditions and consideration of simian T-lymphotropic virus (STLV) status in addition to SIVmnd-1 infection. We found that SIVmnd-1 infection was associated with a significant and progressive loss of memory CD4+ T-cells. Limited but significant increases in markers of immune activation in the T-cell populations, significant increases in plasma neopterin and changes to B-cell subsets were also observed in SIV-infected animals. However, no increase in plasma soluble CD14 was observed. Histological examination of peripheral lymph nodes suggested that SIVmnd-1 infection was not associated with a significant disruption of the lymph node architecture. Whilst this species has evolved numerous strategies to resist the development of AIDS, significant effects of SIV infection could be observed when examined in a natural environment. STLVmnd-1 infection also had significant effects on some markers relevant to understanding SIV infection and thus should be considered in studies of SIV infection of African primates where present. © 2014 SGM.
Authors & Co-Authors
Greenwood, Edward J.D.
United Kingdom, Cambridge
University of Cambridge
Schmidt, Fabian
United Kingdom, Cambridge
University of Cambridge
Liégeois, Florian
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
France, Montpellier
Ird Centre de Montpellier
Kondova, Ivanela I.
Netherlands, Rijswijk
Biomedical Primate Research Centre - Rijswijk
Herbert, Anaïs
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Ngoubangoye, Barthélémy
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Rouet, François
Gabon, Franceville
Centre International de Recherches Medicales de Franceville
Cambodia, Phnom Penh
Institut Pasteur du Cambodge
Heeney, Jonathan
United Kingdom, Cambridge
University of Cambridge
Statistics
Citations: 12
Authors: 8
Affiliations: 5
Identifiers
Doi:
10.1099/vir.0.059808-0
ISSN:
00221317
e-ISSN:
14652099
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Study Approach
Quantitative