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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Molecular modeling study and synthesis of novel pyrrolo[2,3-d]pyrimidines and pyrrolotriazolopyrimidines of expected antitumor and radioprotective activities
Bioorganic and Medicinal Chemistry, Volume 16, No. 5, Year 2008
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Description
Novel pyrrolo[2,3-d]pyrimidine derivatives 4a-e, 10, 14, 15, pyrazolopyrrolopyrimidine 13, pyrrolotriazolopyrimidine 5-9, 17 and pyrrolopyrimidotriazine 18 are reported herein. The design of these compounds was based upon the molecular modeling simulation of the fitting values and conformational energy values of the best-fitted conformers to VEGFRTK inhibitor hypothesis. This hypothesis was generated from its corresponding lead compounds using CATALYST software. The structures of these compounds were confirmed by microanalyses, IR, 1H NMR, and mass spectral data. Compounds 6 and 15 showed interesting in vitro antitumor activity compared to doxorubicin as positive control. These results are nearly consistent with the molecular modeling studies. Docking studies were made on compound 15 to predict its binding mode. Moreover, compound 10 exhibited a significant radioprotective activity. © 2007 Elsevier Ltd. All rights reserved.
Authors & Co-Authors
Abou El-Ella, Dalal A.
Egypt, Cairo
Faculty of Pharmacy - Ain Shams University
Ghorab, Mostafa Mohammed
Egypt, Cairo
National Center for Radiation Research and Technology
Noaman, Eman Ali
Egypt, Cairo
National Center for Radiation Research and Technology
Heiba, Helmy I.
Egypt, Cairo
National Center for Radiation Research and Technology
Khalil, Amira I.
Egypt, Cairo
National Center for Radiation Research and Technology
Statistics
Citations: 62
Authors: 5
Affiliations: 2
Identifiers
Doi:
10.1016/j.bmc.2007.11.072
ISSN:
09680896