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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
biochemistry, genetics and molecular biology
Breast cancer risk in relation to the joint effect of BRCA mutations and diet diversity
Breast Cancer Research and Treatment, Volume 117, No. 2, Year 2009
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Description
It has been suggested that gene-environment interaction is related to the risk of cancer. To evaluate departure from multiplicative effects between BRCA mutations and diet diversity in breast cancer (BC), a case-only study was carried out in a French-Canadian population including 738 patients with incident primary BC comprising 38 BRCA mutation carriers. Diet diversity was assessed using a validated food frequency questionnaire. Unconditional logistic regression analysis was performed to assess case-only odds ratio (COR) and 95% confidence interval (CI) while adjusting for age, body mass index, smoking, hormonal replacement therapy, and total energy intake. Ours results reveal a strong and significant interaction between BRCA mutations and vegetable and fruit diversity (COR = 0.27; 95%CI = 0.10-0.80; P = 0.03) when comparing the upper to the lower quartiles. The estimates for departure from multiplicative effects between BRCA mutations and total or other food groups' diversity were not supportive of the idea of a gene-environment interaction. The results of this study suggest that the combination of BRCA mutations and vegetable and fruit diversity may be associated with a reduced risk of BC. © 2009 Springer Science+Business Media, LLC.
Authors & Co-Authors
Ghadirian, Parviz
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Narod, Steven Alexander
Canada, Toronto
Coalition for Research in Women's Health
Fafard, Eve
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Costa, Myriam
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Robidoux, André
Canada, Montreal
University of Montreal
Canada, Montreal
Centre Hospitalier de L'universite de Montreal
Nkondjock, André
Cameroon, Yaounde
Research Center for Military Health
Cameroon, Yaounde
Military Hospital
Statistics
Citations: 29
Authors: 6
Affiliations: 5
Identifiers
Doi:
10.1007/s10549-008-0292-y
ISSN:
01676806
e-ISSN:
15737217
Research Areas
Cancer
Food Security
Genetics And Genomics
Study Design
Cross Sectional Study
Case-Control Study
Study Approach
Quantitative