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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Alternative mechanisms for tiotropium
Pulmonary Pharmacology and Therapeutics, Volume 22, No. 6, Year 2009
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Description
Tiotropium is commonly used in the treatment of chronic obstructive pulmonary disease. Although largely considered to be a long-acting bronchodilator, its demonstrated efficacy in reducing the frequency of exacerbations and preliminary evidence from early studies indicating that it might slow the rate of decline in lung function suggested mechanisms of action in addition to simple bronchodilation. This hypothesis was examined in the recently published UPLIFT study and, although spirometric and other clinical benefits of tiotropium treatment extended to four years, the rate of decline in lung function did not appear to be reduced by the addition of tiotropium in this study. This article summarizes data from a variety of investigations that provide insights into possible mechanisms to account for the effects of tiotropium. The report summarizes the discussion on basic and clinical research in this field. © 2009 Elsevier Ltd.
Authors & Co-Authors
Bateman, E. D.
South Africa, Cape Town
University of Cape Town
Rennard, Stephen I.
United States, Omaha
College of Medicine
Barnes, Peter John
United Kingdom, London
National Heart and Lung Institute
Dicpinigaitis, P. V.
United States, New York
Montefiore Medical Center
Gosens, R.
Netherlands, Groningen
Rijksuniversiteit Groningen
Gross, Nicholas J.
United States, Chicago
Loyola University Chicago
Nadel, J. A.
United States, San Francisco
University of California, San Francisco
Pfeifer, M.
Germany, Regensburg
Universität Regensburg
Racké, K.
Germany, Bonn
Universität Bonn
Rabe, Klaus F.
Netherlands, Leiden
Leids Universitair Medisch Centrum
Rubin, B. K.
United States, Winston Salem
Wake Forest University School of Medicine
Welte, Tobias
Germany, Hannover
Hannover Medical School
Wessler, I.
Germany, Mainz
Johannes Gutenberg-universität Mainz
Statistics
Citations: 115
Authors: 13
Affiliations: 13
Identifiers
Doi:
10.1016/j.pupt.2009.06.002
ISSN:
10945539
e-ISSN:
15229629