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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Factors that Influence the Reported Sensitivity of Rapid Antigen Testing for SARS-CoV-2
Frontiers in Microbiology, Volume 12, Article 714242, Year 2021
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Description
Tests that detect the presence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antigen in clinical specimens from the upper respiratory tract can provide a rapid means of coronavirus disease 2019 (COVID-19) diagnosis and help identify individuals who may be infectious and should isolate to prevent SARS-CoV-2 transmission. This systematic review assesses the diagnostic accuracy of SARS-CoV-2 antigen detection in COVID-19 symptomatic and asymptomatic individuals compared to quantitative reverse transcription polymerase chain reaction (RT-qPCR) and summarizes antigen test sensitivity using meta-regression. In total, 83 studies were included that compared SARS-CoV-2 rapid antigen-based lateral flow testing (RALFT) to RT-qPCR for SARS-CoV-2. Generally, the quality of the evaluated studies was inconsistent; nevertheless, the overall sensitivity for RALFT was determined to be 75.0% (95% confidence interval: 71.0–78.0). Additionally, RALFT sensitivity was found to be higher for symptomatic vs. asymptomatic individuals and was higher for a symptomatic population within 7 days from symptom onset compared to a population with extended days of symptoms. Viral load was found to be the most important factor for determining SARS-CoV-2 antigen test sensitivity. Other design factors, such as specimen storage and anatomical collection type, also affect the performance of RALFT. RALFT and RT-qPCR testing both achieve high sensitivity when compared to SARS-CoV-2 viral culture. © Copyright © 2021 Parvu, Gary, Mann, Lin, Mills, Cooper, Andrews, Manabe, Pekosz and Cooper.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC8524138/bin/Image_1.JPEG
https://efashare.b-cdn.net/share/pmc/articles/PMC8524138/bin/Image_2.JPEG
https://efashare.b-cdn.net/share/pmc/articles/PMC8524138/bin/Table_1.DOCX
https://efashare.b-cdn.net/share/pmc/articles/PMC8524138/bin/Table_2.DOCX
Authors & Co-Authors
Manabe, Yukari C.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
United States, Baltimore
Johns Hopkins School of Medicine
Pekosz, Andrew S.
United States, Baltimore
Johns Hopkins Bloomberg School of Public Health
United States, Baltimore
Johns Hopkins School of Medicine
Cooper, Charles K.
United States, Sparks
Dickinson and Company
Statistics
Citations: 52
Authors: 3
Affiliations: 3
Identifiers
Doi:
10.3389/fmicb.2021.714242
ISSN:
1664302X
Research Areas
Covid
Study Design
Cross Sectional Study
Study Approach
Quantitative
Systematic review