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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
immunology and microbiology
Genotypic analysis of the protease and reverse transcriptase of HIV type 1 subtype C isolates from antiretroviral drug-naive adults in Malawi
AIDS Research and Human Retroviruses, Volume 21, No. 9, Year 2005
Notification
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Description
The protease (PR) and reverse transcriptase (RT) regions of HIV-1 isolates from 21 antiretroviral (ARV)-naive Malawian adults were sequenced and analyzed to determine the prevalence of drug resistance-associated mutations in this population. Phylogenetic analysis confirmed that all isolates grouped with HIV-1 subtype C, the predominant subtype in Malawi. No major mutations associated with resistance to PR inhibitors (PIs), nucleoside RT inhibitors (NRTIs), or nonnucleoside RT inhibitors (NNRTIs) were found. In contrast, accessory mutations were found in the protease region at positions 10, 20, 36, 63, 77, and 93, and in the RT region at positions 118, 211, and 214. Further studies will be needed to determine the clinical impact of these polymorphisms on viral susceptibility to existing antiretroviral drugs. © Mary Ann Liebert, Inc.
Authors & Co-Authors
Petch, Leslie A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Hoffman, Irving F.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Jere, Charles S.
Malawi, Zomba
University of Malawi
Kazembe, Peter Nicholas
Malawi, Lilongwe
Lilongwe Central Hospital
Martinson, Francis E.A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Chilongozi, David A.T.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Fiscus, Susan A.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Cohen, Myron S.
United States, Chapel Hill
The University of North Carolina at Chapel Hill
Statistics
Citations: 29
Authors: 8
Affiliations: 3
Identifiers
Doi:
10.1089/aid.2005.21.799
ISSN:
08892229
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Study Locations
Malawi