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Publication Details
AFRICAN RESEARCH NEXUS
SHINING A SPOTLIGHT ON AFRICAN RESEARCH
medicine
Feasibility, effectiveness and cost of a decentralized HCV care model among the general population in Delhi, India
Liver International, Volume 42, No. 3, Year 2022
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Description
Background and aims: India has a significant burden of hepatitis C virus (HCV) infection and has committed to achieving national elimination by 2030. This will require a substantial scale-up in testing and treatment. The “HEAD-Start Project Delhi” aimed to enhance HCV diagnosis and treatment pathways among the general population. Methods: A prospective study was conducted at 5 district hospitals (Arm 1: one-stop shop), 15 polyclinics (Arm 2: referral for viral load (VL) testing and treatment) and 62 screening camps (Arm 3: referral for treatment). HCV prevalence, retention in the HCV care cascade, and turn-around time were measured. Results: Between January and September 2019, 37 425 participants were screened for HCV. The median (IQR) age of participants was 35 (26-48) years, with 50.4% male and 49.6% female. A significantly higher proportion of participants in Arm 1 (93.7%) and Arm 3 (90.3%) received a VL test compared with Arm 2 (52.5%, P <.001). Of those confirmed positive, treatment was initiated at significantly higher rates for participants in both Arms 1 (85.6%) and 2 (73.7%) compared to Arm 3 (41.8%, P <.001). Arm 1 was found to be a cost-saving strategy compared to Arm 2, Arm 3, and no action. Conclusions: Delivery of all services at a single site (district hospitals) resulted in a higher yield of HCV seropositive cases and retention compared with sites where participants were referred elsewhere for VL testing and/or treatment. The highest level of retention in the care cascade was also associated with the shortest turn-around times. © 2022 The Authors. Liver International published by John Wiley & Sons Ltd.
Available Materials
https://efashare.b-cdn.net/share/pmc/articles/PMC9299915/bin/LIV-42-532-s001.docx
Authors & Co-Authors
Markby, Jessica
Switzerland, Geneva
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Gupta, Ekta
India, New Delhi
Institute of Liver and Biliary Sciences
Sarin, Sanjay
India, New Delhi
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Ruiz, Ryan Jose I.I.I.
Switzerland, Geneva
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Gaeddert, Mary
Germany, Heidelberg
Universitätsklinikum Heidelberg
Easterbrook, Philippa Jane
Switzerland, Geneva
Organisation Mondiale de la Santé
Sarin, Shiv Kumar
India, New Delhi
Institute of Liver and Biliary Sciences
Shilton, Sonjelle
Switzerland, Geneva
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Statistics
Citations: 3
Authors: 8
Affiliations: 9
Identifiers
Doi:
10.1111/liv.15112
ISSN:
14783223
Research Areas
Infectious Diseases
Study Design
Cross Sectional Study
Cohort Study
Participants Gender
Male
Female